Sökning: "Erik L.L. Sonnhammer"
Hittade 4 avhandlingar innehållade orden Erik L.L. Sonnhammer.
1. Functional association networks for disease gene prediction
Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER
2. In silico modelling for refining gene regulatory network inference
Sammanfattning : Gene regulation is at the centre of all cellular functions, regulating the cell's healthy and pathological responses. The interconnected system of regulatory interactions is known as the gene regulatory network (GRN), where genes influence each other to maintain strict and robust control. LÄS MER
3. Inference of functional association networks and gene orthology
Sammanfattning : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. LÄS MER
4. Improving the accuracy of gene regulatory network inference from noisy data
Sammanfattning : Gene regulatory networks (GRNs) control physiological and pathological processes in a living organism, and their accurate inference from measured gene expression can identify therapeutic mechanisms for complex diseases such as cancers. The biggest obstacle in achieving the accurate reconstruction of GRNs is called ‘noise’, which considerably alters the measured gene expression because the noise generally dominates the biological signal. LÄS MER