Sökning: "Enzyme Activation"

Visar resultat 31 - 35 av 397 avhandlingar innehållade orden Enzyme Activation.

  1. 31. Computational Studies of the Temperature Dependence of Enzyme Catalysis

    Författare :Florian van der Ent; Johan Åqvist; Hugo Gutierrez de Teran; Nigel Richards; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Enzymes are known to adapt to low temperatures by lowering the enthalpy of activation of the key reaction steps. A lesser known property of some psychrophilic (cold-active) enzymes is an anomalous temperature optimum. LÄS MER

  3. 32. Inflammatory activation of the kynurenine pathway : studies with lipopolysaccharides

    Författare :Anthi Faka Schulte; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroinflammation is increasingly recognised as playing an important role in several major psychiatric disorders. The mechanisms by which neuroinflammation influences neurotransmitter systems have for long been unknown. LÄS MER

  4. 33. The Plasma Contact System : New Functional Insights from a Hemostatic and Thrombotic Perspective

    Författare :Jennie Bäck; Bo Nilsson; Kristina Nilsson Ekdahl; Ulla Hedner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Contact activation; factor XII; platelets; coagulation; antithrombin; C1 inhibitor; hemostasis; biomarkers; vascular disease.; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : The physiological role of the plasma contact system still remains a partial enigma. The aim of the presented work was to expand our understanding of the plasma contact system, focusing on its physiological activation and function, principally from a hemostatic perspective. It also explored contact system activation under pathological conditions. LÄS MER

  5. 34. Bridging immune activation with the kynurenine pathway : implications for psychosis

    Författare :Markus Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), an endogenous N-Methyl-D-aspartic acid receptor (NMDAR) antagonist, is elevated in patients with schizophrenia. In addition, elevated levels of KYNA are associated with activation of the immune system, which also has been implicated in the development and maintenance of psychotic disorders, including schizophrenia. LÄS MER

  7. 35. Theoretical studies of mononuclear non-heme iron active sites

    Författare :Arianna Bassan; Per E. M. Siegbahn; Sason Shaik; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; quantum chemistry; enzyme catalysis; iron enzymes; Quantum chemistry; Kvantkemi;

    Sammanfattning : The quantum chemical investigations presented in this thesis use hybrid density functional theory to shed light on the catalytic mechanisms of mononuclear non-heme iron oxygenases, accommodating a ferrous ion in their active sites. More specifically, the dioxygen activation process and the subsequent oxidative reactions in the following enzymes were studied: tetrahydrobiopterin-dependent hydroxylases, naphthalene 1,2-dioxygenase and α-ketoglutarate-dependent enzymes. LÄS MER