Sökning: "factor XII"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden factor XII.

  1. 1. Biomarkers and risk of intracerebral hemorrhage : population-based studies in northern Sweden

    Författare :Kristina Johansson; Marcus Lind; Lars Johansson; Jan-Håkan Jansson; Arne Lindgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intracerebral hemorrhage; hemorrhagic stroke; factor XII; D-dimer; von Willebrand factor; ABO blood groups; phosphatidylethanol; alcohol; risk markers; biomarkers; Medicine; medicin;

    Sammanfattning : BackgroundIntracerebral hemorrhage (ICH) is a disease associated with a high morbidity and mortality and treatment options for the condition are limited. Even though an ICH event usually comes as a surprise to the affected individual, pathogenetic processes often have occurred before the sudden ICH event and may have preceded disease onset by years. LÄS MER

  3. 2. The Plasma Contact System : New Functional Insights from a Hemostatic and Thrombotic Perspective

    Författare :Jennie Bäck; Bo Nilsson; Kristina Nilsson Ekdahl; Ulla Hedner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Contact activation; factor XII; platelets; coagulation; antithrombin; C1 inhibitor; hemostasis; biomarkers; vascular disease.; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : The physiological role of the plasma contact system still remains a partial enigma. The aim of the presented work was to expand our understanding of the plasma contact system, focusing on its physiological activation and function, principally from a hemostatic perspective. It also explored contact system activation under pathological conditions. LÄS MER

  4. 3. Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis

    Författare :Linda Labberton; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Blood coagulation leading to fibrin formation is essential to prevent loss of blood (hemostasis), but can also contribute to occlusion of vessels (thrombosis). Thrombosis causes pulmonary embolism, myocardial infarction and stroke, which are together the most common cause of death in the developed world. LÄS MER

  5. 4. Mechanism and therapy of hereditary angioedema typ III and role of the contact system in inflammatory diseases

    Författare :Jenny Björkqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Combinations of proinflammatory and procoagulant reactions are associated with a variety of disorders affecting the cardiovascular system. Vascular leakage contributes to the pathology of conditions such as, sepsis, allergy and anaphylactic reactions. LÄS MER

  7. 5. The role of platelets in whole blood coagulation

    Författare :Sofia Ramström; Nils Olav Solum; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The body's first line of defence against bleeding is the platelets, small cell fragments with multiple roles in the coagulation process. The platelets are patrolling our blood vessels, looking for damage in the endothelial cell layer, to which they attach and transform, recruit more platelets and assemble the plasma coagulation proteases on their surfaces. LÄS MER