Sökning: "D2-receptors"

Visar resultat 31 - 35 av 40 avhandlingar innehållade ordet D2-receptors.

  1. 31. On striatum in silico

    Författare :Johanna Frost Nylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The basal ganglia are a collection of subcortical nuclei involved in movement and action selection. The striatum is the main input nucleus with extensive projections from the cortex and thalamus, and dopaminergic projections from SNc and VTA. LÄS MER

  3. 32. Striatal signaling in the treatment of Parkinson's disease

    Författare :Irene Sebastianutto; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder characterized by typical motor symptoms that are caused by depletion of dopamine (DA) in the striatum. These symptoms are treated with the DA precursor L-DOPA, or with DA receptor (DAR) agonists. LÄS MER

  4. 33. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism

    Författare :Monika Hellstrand; Göteborgs universitet; []
    Nyckelord :dopamine; dopamine D2 receptor; dopamine D3 receptor; transduction; CHO cells; partial agonism; inverse agonism; arachidonic acid; prostaglandin E2; cAMP; haloperidol; -3-PPP; PNU-99194A; polymorphism; personality;

    Sammanfattning : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. LÄS MER

  5. 34. Modeling Biochemical Network Involved in Striatal Dopamine Signaling

    Författare :Anu G. Nair; Jeanette Hellgren Kotaleski; Omar Gutierrez Arenas; Upinder Singh Bhalla; Jakob Kisbye Dreyer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine signaling; Striatum; Reward learning; Acetylcholine; Mass-action modeling; FRET biosensor; Adenosine; Eligibility trace; Computer Science; Datalogi;

    Sammanfattning : In this thesis, I studied the molecular integration of reward-learning related neuromodulatory inputs by striatal medium-sized projection neurons (MSNs) using mass-action kinetic modeling.It is known that, in reward learning, an unexpected reward results in transient elevation in dopamine (peak) whereas omission of an expected reward leads to transient dopamine decrease (dip). LÄS MER

  7. 35. Regulation by glutamate- and adenosine-receptors of dopamine and acetylcholine release from rat striatal slices

    Författare :Shaoyu Jin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :striatum; dopamine; acetylcholine; adenosine receptors; glutamatereceptors. ISBN 91-628-2599-2;

    Sammanfattning : The striatum, which is critically involved in sensory motor integration, receives an excitatory glutamatergic input from the cerebral cortex and the thalamus. The effects of the glutamatergic stimulation are modulated by dopamine (DA) released from a prominent dopaminergic input, acetylcholine (ACh) released from cholinergic interneurons and by the ubiquitous neuromodulator adenosine. LÄS MER