Sökning: "D2-receptors"

Visar resultat 21 - 25 av 40 avhandlingar innehållade ordet D2-receptors.

  1. 21. Striatal pathways in dyskinesia and dystonia

    Författare :Laura Andreoli; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Dystonia; L-DOPA-induced dyskinesia; DREADD; Mouse model; Dopamine; dopamine receptor;

    Sammanfattning : Purposeful and well-coordinated movements depend on the control exerted by dopamine (DA) on the basal ganglia (BG) network. Accordingly, dysfunctions or lesions of the dopaminergic system in the BG can result in an overall poverty and slowness of movement, cardinal features of Parkinson´s disease (PD), or in dyskinesias, exaggerated and involuntary movements resulting from L-DOPA pharmacotherapy. LÄS MER

  3. 22. Dopaminergic lnterference for Treatment of Schizophrenia and Alcohol Use Disorder - an experimental study in rats

    Författare :Klara Danielsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; striatum; addiction; schizophrenia;

    Sammanfattning : The neurotransmitter dopamine is involved in several different physiological functions as well as pathological conditions. Two conditions that have been suggested to be related to a low dopaminergic tone in the ventral striatum are substance use disorder, and negative symptoms in schizophrenia, both of which are difficult to treat. LÄS MER

  4. 23. Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain

    Författare :Susanne H M Gruber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; D-amphetamine; Antipsychotic drugs; Neurotensin; Neuropeptide Y; Rat brain; Microdialysis;

    Sammanfattning : Schizophrenic patients have been reported to have lower concentrations of neurotensin (NT)-like immunoreactivity (-LI) in their cerebrospinal fluid (CSF) that normalize after treatment with antipsychotic drugs. Schizophrenic patients also had higher CSF concentrations of neuropeptide Y (NPY)-LI compared to controls, thus involvement of NPY in the disease has also been suggested. LÄS MER

  5. 24. Synaptic transmission and synaptic plasticity in the mouse striatum

    Författare :Sietske Schotanus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. LÄS MER

  7. 25. Novel aspects of Na+,K+-ATPase

    Författare :Oleg Aizman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Na; K-A TPase; PKA; PKC; dopamine; ouabain; cell attachment; Ca2 ; oscillations; steroid; transcriptional regulation; IP3R.;

    Sammanfattning : Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and regulation. It is well established that Na,K-ATPase activity is regulated by reversible phosphorylation. LÄS MER