Sökning: "D2-receptors"

Visar resultat 36 - 40 av 40 avhandlingar innehållade ordet D2-receptors.

1. 36. Dopaminergic and serotonergic modulation of cellular and locomotor network properties in the lamprey spinal cord

   Författare :Martin Wikström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :5-hydroxytryptamine; Dopamine; Calcium channels; Calcium-dependent potassium channels; Afterhyperpolarization; Membrane potential oscillation; Synaptic transmission; Modulation; Central pattern generator; Locomotion; Spinal cord; Lamprey;

   Sammanfattning : Motor activity is the basis for all behavior. It is therefore important to study the processes generating movement such as the neuronal networks in the spinal cord that generates and controls locomotion. The lamprey is used as a model system for the study of locomotion. LÄS MER

3. 37. Molecular mechanisms underlying the actions of psychoactive drugs in the basal ganglia : focus on cannabinoids and morphine

   Författare :Anders Borgkvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis is centered on the identification of the molecular mechanisms involved in the psychomotor effects of cannabinoids and morphine. These drugs share the ability of acting at the level of the basal ganglia, a group of subcortical structures involved in the control of locomotion, as well as in cognitive and motivational aspects of motor function. LÄS MER

4. 38. Neuromodulation shapes interneuron communication in the mouse striatum

   Författare :Matthijs Constantijn Dorst; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of subcortical nuclei that have been demonstrated to be involved in motor function and reward, amongst other functions. LÄS MER

5. 39. Ion channels and intrinsic membrane properties of locomotor network neurons in the lamprey spinal cord

   Författare :Di Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ion channels; calcium activated non-selective cation current ICAN ; L-type LVA calcium channels Cav 1.3 ; calcium channels; calcium imaging; NMDA; postinhibitory rebound PIR ; lamprey; central pattern generator CPG ; locomotion;

   Sammanfattning : NMDA-receptor dependent membrane potential oscillations and postinhibitory rebound are examples of intrinsic membrane properties of many neurons of rhythm-generating networks, and are considered to play major roles in the operation of the spinal locomotor network of the lamprey vertebrate model. A significant feature of many lamprey spinal cord neurons is their ability to generate pacemaker-like membrane potential oscillations in the presence of the glutamate agonist NMDA. LÄS MER

7. 40. Pharmacological and genetic modulation of adult neurogenesis in animal models relevant to neuropsychiatric disorders

   Författare :Martin Thor Egeland; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : During the past decade, the modulation of adult neurogenesis has been an intensively studied area of neuroscience due to the implications for understanding of physiological mechanisms in the adult brain and the potential clinical applications for neuropsychiatric disorders. This research has resulted in countless discoveries during a relatively short period of time elucidating mechanistic details about where adult neurogenesis takes place, how the process of neurogenesis occurs and how this process can be regulated at several different steps by, not only endogenous mechanisms which normally maintain a homeostasis of adult neurogenesis, but also by exogenous regulation using genetic and pharmacological modulations to manipulate steps of the process. LÄS MER