Sökning: "D2 D3 receptors"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden D2 D3 receptors.

  1. 1. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism

    Författare :Monika Hellstrand; Göteborgs universitet; []
    Nyckelord :dopamine; dopamine D2 receptor; dopamine D3 receptor; transduction; CHO cells; partial agonism; inverse agonism; arachidonic acid; prostaglandin E2; cAMP; haloperidol; -3-PPP; PNU-99194A; polymorphism; personality;

    Sammanfattning : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. LÄS MER

  3. 2. Voltage sensitivity of dopamine D2-like receptors

    Författare :Kristoffer Sahlholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands. LÄS MER

  4. 3. Dopamine D2 and D3 receptors: studies on transduction mechanisms and the role of a D3 gene polymorphism

    Författare :Monika Hellstrand; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER

  5. 4. Dopamine receptors in the rat brain

    Författare :Mi Hillefors-Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine D2 receptors; Dopamine D3 receptors; Rat; Autoradiography; [3H]7-OH-DPAT; [3H]PD 128907; Caudate-putamen; Subcortical limbic area; Islands of Calleja; CGS 21680; Toluene; Neurotensin; Asphyxia; Aging; Magnesium; GTP;

    Sammanfattning : Dopamine receptors belong to a large superfamily of G protein-coupled receptors and consist of the D1, D2, D3, D4, and D5 receptors. The D2, D3, and D4 receptors belong to the D2 receptor family which is characterized by having a large third cytoplasmic loop and a short C-terminus projecting into the cytosol, and by inhibiting the enzyme adenylyl cyclase. LÄS MER

  7. 5. Methological advances in the examination of the dopamine system in brain

    Författare :Judit Sóvágó; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine-D2 D3 receptors; brain; [35S]GTPgS binding autoradiography; positron emission tomography; partial volume effect;

    Sammanfattning : The dopamine (DA) system in brain has attracted considerable attention in neuroscience due to its involvement in fundamental brain functions and its postulated role in the pathophysiology of several neuropsychiatric disorders. Radioligand binding techniques in vitro and in vivo, such as receptor binding autoradiography and positron emission tomography (PET) have substantially contributed to our understanding of the DA system. LÄS MER