Sökning: "Cys"
Visar resultat 1 - 5 av 60 avhandlingar innehållade ordet Cys.
1. Modulating Enzyme Functions by Semi-Rational Redesign and Chemical Modifications : A Study on Mu-class Glutathione Transferases
Sammanfattning : Today, enzymes are extensively used for many industrial applications, this includes bulk and fine-chemical synthesis, pharmaceuticals and consumer products. Though Nature has perfected enzymes for many millions of years, they seldom reach industrial performance targets. LÄS MER
2. Elucidating the Gating Mechanism of Cys-Loop Receptors
Sammanfattning : Cys-loop receptors are membrane proteins that are key players for the fast synaptic neurotransmission. Their ion transport initiates new nerve signals after activation by small agonist molecules, but this function is also highly sensitive to allosteric modulation by a number of compounds such as anesthetics, alcohol or anti-parasitic agents. LÄS MER
3. Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation
Sammanfattning : The homeostasis of intracellular redox status has a crucial role in the cell survival and different processes such as DNA synthesis, gene expression, enzymatic activity, etc. This homeostasis is achieved via an intense balance between pro-oxidants and anti-oxidants. LÄS MER
4. Sulfur amino acids and their metabolites in patients with renal failure : relation to nutritional status and cardiovascular disease
Sammanfattning : Patients with chronic renal failure (CRF) have a high prevalence of cardiovascular disease (CVD), malnutrition and diabetes mellitus (DM) and exhibit several abnormalities in amino acid metabolism. The aims of this thesis were to assess alterations in sulfur amino acids and related sulfur compounds in relation to nutritional status, CVD and DM in CRF patients. LÄS MER
5. Synthesis, Characterization and Application of 68Ga-labelled Peptides and Oligonucleotides
Sammanfattning : The positron emitting 68Ga radionuclide (T1/2 = 68 min) has the potential of practical interest for clinical PET. The metallic cation, 68Ga3+, is suitable for complexation reactions with chelators either naked or conjugated with macromolecules such as peptides and oligonucleotides. LÄS MER