Sökning: "Conformational investigations"

Visar resultat 6 - 10 av 36 avhandlingar innehållade orden Conformational investigations.

  1. 6. Structure, dynamics and interactions of biomolecules : Investigations by NMR spectroscopy and computational methods

    Författare :Jens Landström; Göran Widmalm; Pedro Nieto; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; MD simulation; carbohydrate synthesis; protein-ligand interaction; glycosyltransferase; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : In this thesis, the structure, dynamics and interactions of proteins and carbohydrates are investigated using mainly NMR spectroscopy and computer simulations. Oligosaccharides representing a Salmonella O-antigen have been synthesized and their dynamic behavior and interaction with the bacteriophage P22 tail-spike protein have been studied by NMR spectroscopy, MD and docking simulations. LÄS MER

  3. 7. Synthesis of oligosaccharides and conformational analysis by NMR spectroscopy

    Författare :Jerk Rönnols; Göran Widmalm; Eszter Borbas; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Sammanfattning : The first part of this thesis describes investigations of the conformations of six N-linked pseudodisaccharides (Paper I), which were synthesized as glycosidase inhibitor candidates, and 10 β-D-xylopyranoside derivatives bearing hydrophobic aglycons (Paper II), by NMR spectroscopic methods. In paper I the ring conformations of 2- and 3-amino-α-D-altropyranosides, and ω torsions of altrosides, glucosides and mannosides were described, in neutral and protonated states. LÄS MER

  4. 8. Investigations of chemical and enzymatic functionalization of affinity proteins

    Författare :Anders Myrhammar; Amelie Eriksson Karlström; Per-Åke Nygren; Christian Heinis; KTH; []
    Nyckelord :Affinity protein; affibody; conjugation; solid phase peptide synthesis; proteolytic stability; peptide nucleic acid PNA .; Bioteknologi; Biotechnology;

    Sammanfattning : AbstractAffinity proteins are important reagents in research, diagnostics and therapeutic settings. The focus of this thesis has been on investigating different chemical and enzymatic strategies for engineering of affinity proteins to generate affinity reagents with improved or changed functionality. LÄS MER

  5. 9. Synthesis of Conformationally Restricted Oligosaccharides

    Författare :Michael Wilstermann; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Streptococcus suis; E. coli; neoglycolipid; ganglioside-lactam; xylose; methylene acetal; sialic acid; Conformational Restriction; galabiose; Organic chemistry; Organisk kemi;

    Sammanfattning : Gangliosides are sialic acid-containing glycosphingolipids that often are present in increased amounts on tumor cells. Since the gangliosides are hydroxy-acids, they can form lactones. The lactones have been suspected to be more immunogenic than the open forms, but are in practise poor immunogens due to their ease of hydrolysis. LÄS MER

  7. 10. Triplet Excitation Energy Transfer in Donor-Bridge-Acceptor Systems: Experimental and Theoretical Investigations

    Författare :Mattias P Eng; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; self-assembled monolayer; density functional theory; triplet excitation energy transfer; gold porphyrin; electron transfer; spectroscopy; superexchange; electronic coupling;

    Sammanfattning : This thesis is a contribution to the understanding of bridge mediation of electron exchange processes in Donor-Bridge-Acceptor (D-B-A) systems. The field of research is relevant for the development and optimization of dye-sensitized solar cells, artificial photosynthesis, and the possible future development of molecular electronic devices. LÄS MER