Sökning: "CLOCK genes"

Visar resultat 11 - 15 av 38 avhandlingar innehållade orden CLOCK genes.

  1. 11. Bioinformatic and Biostatistic Analysis of Epigenetic Data from Humans and Mice in the Context of Obesity and its Complications

    Författare :Sarah Voisin; Helgi Schiöth; Claudine Junien; Romain Barres; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; obesity; genetics; epigenetics; DNA methylation; sleep; developmental origins of health and disease; single nucleotide polymorphism; genome-wide association study;

    Sammanfattning : Worldwide obesity has more than doubled since 1980 and at least 2.8 million people die each year as a result of being overweight or obese. An elevated body weight is the result of the interplay between susceptibility gene variants and an obesogenic environment, and recent evidence shows that epigenetic processes are likely involved. LÄS MER

  3. 12. Functional genomics of diapause in two temperate butterflies

    Författare :Peter Pruisscher; Karl Gotthard; Dieter Ebert; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diapause induction; adaptation; genomics; transcriptomics; populationsgenetik; Population Genetics;

    Sammanfattning : Natural selection will act on a given phenotype to maximize fitness in a particular environment, even if this would result in reduced fitness in other environments. In insects some of the strongest selection pressures act on timing life cycles to seasonal variation in environmental conditions, in order to maximize growth, reproduction, and to anticipate the onset of winter. LÄS MER

  4. 13. Circadian rhythms in the auditory system

    Författare :Vasiliki Basinou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Circadian clocks have been found in numerous cell types and tissues of the body, allowing organisms to coordinate their daily biological functions. They generate cycles of behavioral and physiological processes with a period length of ~24h, which are synchronized to the rotation of the Earth and the subsequent daily changes in illumination, temperature and humidity. LÄS MER

  5. 14. Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance

    Författare :Evangelia Tserga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are poorly understood. LÄS MER

  7. 15. Conifer Evolution, from Demography and Local Adaptation to Evolutionary Rates : Examples from the Picea genus

    Författare :Jun Chen; Martin Lascoux; Ulf Lagercrantz; Matt Olson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Speciation; Demographics; clinal variation; convergent evolution; transcriptome; small regulatory RNA; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Evolutionary process can be inferred at three different levels: the species level, the population level and the molecular level. In this thesis, I applied approaches at these three levels and aimed to get a comprehensive picture of conifer evolution, from speciation and demography to geographic variation and local adaptation, and then to the molecular evolution of proteins and small regulatory RNAs. LÄS MER