Sökning: "CLOCK genes"

Visar resultat 16 - 20 av 38 avhandlingar innehållade orden CLOCK genes.

  1. 16. Regulation of chromatin transitions in the 3D architecture of the nucleus

    Författare :Honglei Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation capture assay (4C) and Chromatin in situ Proximity (ChrISP) technique to uncover an inter-chromosomal chromatin fiber interactome comprising both transcriptionally active circadian genes and repressed lamina-associated domains (LADs). LÄS MER

  3. 17. Deciphering the role of genetics and circadian rhythm in cluster headache

    Författare :Carmen Fourier; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cluster headache (CH) is a complex neurovascular disorder with a distinct circadian attack pattern. Although many aspects of the disease’s pathophysiology remain to be elucidated, it is likely caused by a combination of different genetic and environmental risk factors. LÄS MER

  4. 18. Genetic and experimental studies of seasonal affective disorder and related phenotypes

    Författare :Carolina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Seasonal affective disorder (SAD) is a subtype of recurrent depressive or bipolar disorder, in which episodes reoccur and remit during a particular season each year. A genetic component in vulnerability to winter SAD has been suggested, and the goal of this thesis was to increase the understanding of SAD and seasonal variations in mood, by obtaining self-report assessments of related traits, examining genetic variations in genes hypothesised to influence the phenotypes in question, and to investigate effects of different photoperiods and stress in an animal model. LÄS MER

  5. 19. Rates and patterns of bryophyte molecular evolution

    Författare :Anna-Malin Linde; Ulf Lagercrantz; Nils Cronberg; D. Magnus Eklund; Jonathan Shaw; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics;

    Sammanfattning : Plants have been growing on land for at least 450 million years. The bryophytes comprising the three phyla liverworts, mosses and hornworts, are considered to be the closest extant relatives to the plants that colonized land. LÄS MER

  7. 20. Circadian plasticity in the neuromuscular junction of Drosophila melanogaster

    Författare :Kerstin Mehnert; Rafael Cantera; Charlotte Helfrich-Förster; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurobiology; Neurobiologi; funktionell morfologi; Functional Zoomorphology;

    Sammanfattning : A biological clock exists in many organisms and controls rhythmic behaviors such as the activity pattern of locomotion. At the cellular level, it has been shown that circadian rhythms in the morphology of neurons exist in the fruit fly Drosophila melanogaster. LÄS MER