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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Development of Methods in CE, CE-MS and MS/MS : Applications in Pharmaceutical, Biomedical and Forensic sciences

   Författare :Emmy Jäverfalk-Hoyes; Jonas Bergquist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

   Sammanfattning : Capillary electrophoresis-mass spectrometry has been used successfully for the analysis of a wide range of analytes such as chiral local anaesthetics, sulphonated reactive dyes and endogenous neurotransmitters and neuropeptides.The partial filling technique was used in CE-MS for chiral separation of bupivacaine and ropivacaine using the non-volatile selector β-cyclodextrin. LÄS MER

3. 2. Mass spectrometry based analysis of drugs, neurotransmitters and lipids in invertebrate model systems

   Författare :Nhu TN Phan; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; CE-MS; Imaging mass spectrometry; Lipids; Neurotransmitters; Drug; Drosophila; C. elegans;

   Sammanfattning : Mass spectrometry (MS) is one of the most universal analytical techniques due to its label-free detection principle and high chemical specificity, high selectivity, and sensitivity. MS is diverse with many different types of systems to meet different analytical demands from various research areas. LÄS MER

4. 3. Spatial metabolomics using Surface Sampling Capillary Electrophoresis Mass Spectrometry  : New tool for direct surface sampling chemical analysis of biological samples

   Författare :Anastasia Golubova; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Analytical surface sampling tools enable direct chemical studies of solid biological samples, including morphologically diverse tissue, and provide both fast chemical analysis with minimum sample preparation and information about molecular spatial distribution. Spatially resolved investigations of tissue sections could help to reveal pathological mechanisms at specific tissue locations. LÄS MER

5. 4. Tailormade Surfaces for Extended CE Applications

   Författare :Sara Ullsten; Karin Markides; Staffan Folestad; Gerhardus J de Jong; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis; mass spectrometry; surface properties; coatings; polymers; liposomes; proteins; drugs; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : The combination of capillary electrophoresis (CE) and mass spectrometry (MS) constitutes a powerful microanalytical system in the fields of biology, medicine and chemistry. This thesis describes the development of three novel capillary coatings and demonstrates how these extend the utility of CE as a high-efficiency separation technique in protein analysis and biopharmaceutical drug screening. LÄS MER

7. 5. Column Development in Capillary Electrophoresis and Electrochromatography for Bioanalytical Applications

   Författare :Nina Johannesson; Jonas Bergquist; Karin Markides; Abdul Malik; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Capillary electrophoresis CE ; Capillary electrochromatography CEC ; Mass spectrometry MS ; Bioanalysis; Sample pretreatment; Sol-gel; Analytisk kemi;

   Sammanfattning : Analysis of biological samples can be a difficult task. This thesis covers a broad aspect of the analytical areas of capillary electrophoresis (CE) and capillary electrochromatography (CEC) in combination with mass spectrometry (MS) that are of great importance for achieving fast, accurate and sensitive bioanalyses. LÄS MER