Sökning: "Bioteknologi"

Visar resultat 21 - 25 av 1000 avhandlingar innehållade ordet Bioteknologi.

  1. 21. Autoantibody profiling in autoimmune diseases

    Författare :Shaghayegh Bayati; Peter Nilsson; Elisa Pin; Peter Heeringa; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; Autoantibodies; Vasculitis; Systemic Sclerosis; affinity proteomics; Biotechnology; Bioteknologi;

    Sammanfattning : Autoimmune disease diagnosis and definition of prognosis can be challenging. Patients with the same autoimmune disease could present with very heterogeneous symptoms. Therefore, there is a need to understand the disease better to improve patients’ diagnosis, and classification, and tailor the treatment. LÄS MER

  3. 22. Spatial Tissue Mapping on Joint Biopsies from Arthritis Patients

    Författare :Konstantin Carlberg; Patrik Ståhl; Vivianne Malmström; Anna-Karin Hultgård Ekwall; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune prediction; Rheumatoid arthritis; Spatial RIN; Spatial Transcriptomics; Spondyloarthritis; Bioteknologi; Biotechnology;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects joints, causing discomfort and pain that severely reduces the life quality of affected individuals. Its etiology is largely unknown, but some pathophysiological mechanisms have been identified. LÄS MER

  4. 23. Barcoded DNA Sequencing for Parallel Protein Detection

    Författare :Mahya Dezfouli; Afshin Ahmadian; Ulf Landegren; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA barcoding; antibody labeling; antibody oligonucleotide bio-conjugation; DNAassisted proteomics; immuno-sequencing I-Seq ; droplet-based system; large-scale data analysis; Biotechnology; Bioteknologi;

    Sammanfattning : The work presented in this thesis describes methodologies developed for integration and accurate interpretation of barcoded DNA, to empower large-scale-omics analysis. The objectives mainly aim at enabling multiplexed proteomic measurements in high-throughput format through DNA barcoding and massive parallel sequencing. LÄS MER

  5. 24. On the application and validation of multiplexed affinity assays

    Författare :Tea Dodig-Crnković; Jochen M. Schwenk; Mun-Gwan Hong; Peter Nilsson; Norman Leigh Anderson; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity proteomics; Antibody; Autoantibody; Multiplexed assays; Protein microarray; Plasma proteins; Suspension bead array; Bioteknologi; Biotechnology;

    Sammanfattning : Proteins are essential macromolecules that carry out complex functions in human cells, tissues, and organs. They regulate a diverse set of biological processes and protect against pathogens. However, dysregulation or malformation of proteins can cause disease. LÄS MER

  7. 25. Bioparticle Manipulation using Acoustophoresis and Inertial Microfluidics

    Författare :Muhammad Asim Faridi; Aman Russom; Martin Wiklund; Jonas Tegenfeldt; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biotechnology; Bioteknologi;

    Sammanfattning : Despite the many promising advances made in microfluidics, sample preparation remains the single largest challenge and bottleneck in the field of miniaturised diagnostics. This thesis is focused on the development of sample preparation methods using active and passive particle manipulation techniques for point of care diagnostic applications. LÄS MER