Sökning: "protein families"

Visar resultat 1 - 5 av 267 avhandlingar innehållade orden protein families.

  1. 1. An evolutionary basis for protein design and structure prediction

    Författare :Christoffer Norn; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein evolution; Biophysics; Protein design; Protein structure prediction;

    Sammanfattning : The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design new protein functions. LÄS MER

  3. 2. Structural Information and Hidden Markov Models for Biological Sequence Analysis

    Författare :Jeanette Tångrot; Bo Kågström; Uwe H. Sauer; Erik Sonnhammer; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; HMM; structure alignment; protein structure; secondary structure; remote homologue; annotation; domain family; protein family; protein superfamily; protein fold recognition; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatics is a fast-developing field, which makes use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins, which is often based on finding relationships to already characterized proteins. LÄS MER

  4. 3. Characterization of protein families, sequence patterns, and functional annotations in large data sets

    Författare :Anders Bresell; Bengt Persson; Inge Jonassen; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; sequence analysis; patterns; protein families; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatics involves storing, analyzing and making predictions on massive amounts of protein and nucleotide sequence data. The thesis consists of six papers and is focused on proteins. LÄS MER

  5. 4. Prediction of function shift in protein families

    Författare :Saraswathi Abhiman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Protein function; Divergence; Function shift; Subfamily;

    Sammanfattning : With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational methods can predict broad functionality for most protein sequences, there is room for improvement in order to get more precise functional annotation. LÄS MER

  7. 5. Studies of the Ribosomal Protein S19 in Erythropoiesis

    Författare :Hans Matsson; Niklas Dahl; Leif Carlsson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; RPS19; Rps19; erythropoiesis; erythroblastopenia; Diamond-Blackfan; anemia; Genetik; Genetics; Genetik;

    Sammanfattning : Ribosomal proteins are components of the ribosome, the protein synthesis machinery. The ribosomal protein S19 gene (RPS19) is mutated in Diamond-Blackfan anemia, DBA, which is a rare congenital anemia with absence or reduction of erythroid precursors in bone marrow. In this thesis, the role of RPS19 in erythropoiesis is investigated. LÄS MER