Sökning: "Bioinformatik"

Visar resultat 11 - 15 av 439 avhandlingar innehållade ordet Bioinformatik.

  1. 11. Computational Modelling of Gene Regulation in Cancer : Coding the noncoding genome

    Författare :Husen Muhammad Umer; Jan Komorowski; Claes Wadelius; Jan Korbel; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Regulatory elements; gene regulation; cancer; motif; integrative database; software solutions for cancer data; Bioinformatics; Bioinformatik;

    Sammanfattning : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. LÄS MER

  3. 12. High Confidence Network Predictions from Big Biological Data

    Författare :Rasmus Magnusson; Mika Gustafsson; Elin Nyman; Andreas Tjärnberg; Jan Komorowski; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Biology functions in a most intriguing fashion, with human cells being regulated by multiplex networks of proteins and their dependent systems that control everything from proliferation to cell death. Notably, there are cases when these networks fail to function properly. LÄS MER

  4. 13. Development and Application of Computational Models for Peptide-Protein Complexes

    Författare :Isak Johansson-Åkhe; Björn Wallner; Claudio Mirabello; Maria Sunnerhagen; Ora Schueler-Furman; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Protein-protein interactions between a protein and a smaller protein fragment or a disordered segment of a protein are called peptide-protein interactions. Such interactions are commonplace in nature and vital for normal cell function in humans. LÄS MER

  5. 14. Decipher protein complex structures from sequence

    Författare :Wensi Zhu; Arne Elofsson; Nathalie Reuter; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein complex structure prediction; protein interaction; AI; AlphaFold; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Sammanfattning : Proteins are essential constituents of biological systems. A profound understanding of protein structure is significant for unraveling the intricate mechanisms of biological processes. The recent development of computational methods using AI technology is revolutionizing the structural biology field. LÄS MER

  7. 15. Mutational effects on protein structure and function

    Författare :Jonas Carlsson; Persson Bengt; Uwe Sauer; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mutation; prediction; phenotypes; homology model; virtual screening; molecular dynamics; amyloid; cancer; membrane protein; Bioinformatics; Bioinformatik;

    Sammanfattning : In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. LÄS MER