Sökning: "BRAF mutation"

Visar resultat 6 - 10 av 27 avhandlingar innehållade orden BRAF mutation.

  1. 6. Molecular Genetic Studies on Prostate and Penile Cancer

    Författare :Patiyan Andersson; Peter Söderkvist; Mattias Höglund; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; IRS1; penile cancer; hTERT; FHIT; PIK3CA; HRAS; KRAS; NRAS; BRAF; Oncology; Onkologi;

    Sammanfattning : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. LÄS MER

  3. 7. Data analysis for discovering the protein profile dynamics of the human ovarian follicular fluid and BRAF mutated metastatic melanoma tissue. : -

    Författare :Indira Pla Parada; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; data analysis; malignant melanoma; ovarian follicular fluid; reproduction; bioinformatics; mass spectromery; female infertility;

    Sammanfattning : Proteomics is widely utilized to understand the function of cellular processes at the molecular level. Using liquid chromatography interfaced with mass spectrometry (LC-MS)-based proteomics, thousands of proteins can be identified and quantified in a single experiment and their relationship and interactions can be analyzed. LÄS MER

  4. 8. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Författare :Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Sammanfattning : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). LÄS MER

  5. 9. Molecular studies in different types of melanoma tumors : correlations to clinical data

    Författare :Abdlsattar Zebary; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Approximately 90% of melanomas arise from skin sites (known as cutaneous malignant melanoma; CMM), whereas the non-cutaneous melanoma (mucosal and ocular melanomas) are rare, accounting for about 10%. Familial melanoma accounts for up to 10% of patients diagnosed with CMM. Both genetics (e.g. LÄS MER

  7. 10. Mutations and molecular signatures in human melanoma

    Författare :Braslav Jovanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous melanoma is a disease which results from a complex mixture of various extrinsic and intrinsic factors, with some major players still unknown. Although primary tumors are highly curable with surgical excision, particularly those which are non-ulcerated and have a thickness of less than 1 mm, poor survival rates are observed in advanced disease. LÄS MER