Sökning: "HRAS"

Hittade 3 avhandlingar innehållade ordet HRAS.

1. 1. Molecular Genetic Studies on Prostate and Penile Cancer

   Författare :Patiyan Andersson; Peter Söderkvist; Mattias Höglund; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; IRS1; penile cancer; hTERT; FHIT; PIK3CA; HRAS; KRAS; NRAS; BRAF; Oncology; Onkologi;

   Sammanfattning : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. LÄS MER

3. 2. Genetic and molecular background of pheochromocytoma and paraganglioma

   Författare :Adam Stenman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pheochromocytomas (PCC) and abdominal paragangliomas (PGL), collectively denoted PPGL, are neuroendocrine tumors (NET) with a highly diverse genetic and molecular etiology, arisen in the adrenal medulla and abdominal paraganglia respectively. The tumors often cause cardiovascular symptoms due to the high production of catecholamines, and malignancy occurs in 10% of the PCCs and 30% of the PGLs. LÄS MER

4. 3. Molecular genetic analysis of human breast cancer

   Författare :Catherine M Phelan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cancer being implicated in 5-10% of these cases. Two highly penetrant hereditary breast cancer genes are known; BRCA1 (17q) and BRCA2 (13q), which also confer an increased risk of cancer at other sites. LÄS MER