Sökning: "BRAF mutation"
Visar resultat 21 - 25 av 27 avhandlingar innehållade orden BRAF mutation.
21. Liquid biopsies in pediatric oncology : towards clinical implementation
Sammanfattning : During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies could serve many purposes in childhood oncology as well. LÄS MER
22. Clinical and epidemiological studies on prognostic and predicitve factors in cutaneous melanoma
Sammanfattning : Background: Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in Sweden, as in many other western countries. In clinical practice, the histopathological evaluation has remained the basis for staging the CMMs and, thus, providing important information on prognosis and on therapeutic recommendations. LÄS MER
23. Staging and therapy response in rectal cancer
Sammanfattning : Every year, around 2,200 individuals are diagnosed with rectal cancer in Sweden. As a result of better tumour staging using magnetic resonance imaging (MRI), pre-operative radiotherapy (with or without chemotherapy), and improved surgery, outcome has improved substantially during the past few decades. LÄS MER
24. Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer
Sammanfattning : Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes and loss of function mutations in tumor suppressor genes. LÄS MER
25. Molecular genetic aspects of colorectal cancer development
Sammanfattning : Colorectal cancer (CRC) is one of the most common cancer diseases in the world after lung and female breast cancer and approximately 945 000 new cases are diagnosed every year. CRC is caused by genetic alterations in the DNA, which results in cell cycle acceleration, escape from apoptosis, senescence, angiogenesis, invasion and metastasis. LÄS MER