Sökning: "BRAF mutation"

Visar resultat 11 - 15 av 27 avhandlingar innehållade orden BRAF mutation.

  1. 11. Activating proto-oncogene mutations in human cutaneous melanoma

    Författare :Katarina Omholt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary melanoma; 4) vertical growth phase (VGP) primary melanoma; and 5) metastatic melanoma. LÄS MER

  3. 12. Hitting the right targets : a study of molecular mediators of sensitivity to novel potential targeted therapies in cutaneous malignant melanoma

    Författare :Ishani Das; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer with a 5-year overall survival (OS) rate of less than 10% among patients diagnosed with disseminated disease. During the past decade the emergence and use of novel targeted therapy and immunotherapy has significantly increased the 5-year OS rate (34%). LÄS MER

  4. 13. Development of individualized surgical treatments for malignant melanoma

    Författare :Valerio Belgrano; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; sentinel node; isolated limb perfusion; immune-humanized xenograft mouse models; translational research;

    Sammanfattning : Background: Cutaneous melanoma is a malignancy with an increasing incidence worldwide, especially in northern Europe. The aim of this thesis is to scrutinize the results achieved by traditional surgery and the opportunities offered by translational research for the more advanced stages of the disease. LÄS MER

  5. 14. Prognostic and Predictive Somatic Mutations in Colorectal Cancer

    Författare :Luís Nunes; Tobias Sjöblom; Bengt Glimelius; Snehangshu Kundu; Ivaylo Stoimenov; Laura DeLong Wood; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; somatic mutations; next-generation sequencing; whole-genome sequencing; transcriptomics; targeted therapy; prognosis; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Colorectal cancer (CRC) is the third most incident and the second deadliest cancer worldwide. Even though CRC incidence is strongly correlated with age, it has been increasing in developing countries and younger individuals. LÄS MER

  7. 15. Molecular aspects of post-Chornobyl and sporadic papillary thyroid carcinoma

    Författare :Andrii Dinets; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :papillary thyroid carcinoma;

    Sammanfattning : Papillary thyroid carcinoma (PTC) exhibits various molecular abnormalities, both when sporadic and radiation-related. PTC is still diagnosed in adult individuals who were younger than 18 years at the time of the Chornobyl accident in 1986 and lived within the contaminated area. LÄS MER