Sökning: "comparative genomic hybridisation"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden comparative genomic hybridisation.

  1. 1. Hopeful monsters: The role of hybrids in adaptation : The impact of hybridisation and genetic diversity on adaptation to stressful and novel environments

    Författare :Ciaran Gilchrist; Rike Stelkens; Christopher Wheat; Linda Laikre; Mathilde Cordellier; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Experimental evolution; Saccharomyces cerevisiae; population genetics; hybridisation; adaptation; aneuploidy; comparative genomics; evolve-and-resequence; de novo mutations; evolutionary parallelism; populationsgenetik; Population Genetics;

    Sammanfattning : Adaptation to novel environments can only occur if natural selection has the raw material to act upon. But small, endangered populations are often genetically depleted, and the acquisition of beneficial de novo mutations often takes too long when population face quick and extreme environmental change. LÄS MER

  3. 2. Pheochromocytoma and abdominal paraganglioma : clinical and genetic aspects

    Författare :Elisabet Edström Elder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pheochromocytomas; abdominal paragangliomas; RET; MEN 2A; tumour development; chromosome 1; comparative genomic hybridisation; in situ hybridization; loss of heterozygosity.;

    Sammanfattning : Pheochromocytomas and abdominal paragangliomas are rare catecholamine producing tumours arising from sympathoadrenal paraganglia located within and outside of the adrenal medulla, respectively. The great majority of tumours are benign and cured by surgery. LÄS MER

  4. 3. Trypanosoma cruzi genome plasticity and evolution

    Författare :Carlos Talavera-López; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Trypanosoma cruzi, a protozoan from the Kinetoplastidae family, is the etiologic agent of Chagas disease, a major public health problem affecting mostly the poorest areas of Latin America. Due to the complex nature of the parasite’s genome it has been impossible to produce a complete reference genome sequence, thus hampering the implementation of post- genomic approaches to unveil the mechanisms of generation of antigenic variation and the identification of new drug targets. LÄS MER

  5. 4. Aspects on local recurrence after rectal cancer surgery

    Författare :Karl Kodeda; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rectal neoplasms; Neoplasms recurrence; local; Methodology; Rectal washout; Rectal irrigation; Anterior resection; Quality assurance registry; Follow-up; Array-CGH; Tumour DNA;

    Sammanfattning : Background: Local recurrence after rectal cancer surgery has a profound impact on affected patients’ lives. The overall aim of this thesis was to acquire a deeper understanding of local recurrence after rectal cancer surgery, with a long-term hope of minimising the incidence and mitigating the effects. LÄS MER

  7. 5. Molecular Characterisation of Structural Chromosomal Abnormalities Associated with Congenital Disorders

    Författare :Mahmoud R. Mansouri; Niklas Dahl; Hans Van Bokhoven; Uppsala universitet; []
    Nyckelord :Genetics; Chromosomal abnormalities; Mental retardation; Hypospadias and anal malformation; Premature ovarian failure; Autism; Array-CGH; ZDHHC15; Genetik;

    Sammanfattning : Chromosomal abnormalities are defined as changes in the chromosome structure and fall in one of two categories. The first category is numerical alterations while the second category consists of structural abnormalities. Structural chromosomal abnormalities do not always interrupt genes in order to cause disease. LÄS MER