Sökning: "Alpha synuclein"

Visar resultat 11 - 15 av 52 avhandlingar innehållade orden Alpha synuclein.

1. 11. Oligodendroglial (dys)function in alpha-synucleinopathies

   Författare :Carla Azevedo; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synucleinopathies; iPSCs; oligodendrocytes; alpha-synuclein; HLA; cell maturation; immunoproteasome;

   Sammanfattning : The complexity of a-synucleinopathies, which include multiple system atrophy (MSA) and Parkinson’s disease (PD), is not entirely understood. It is known that pathological accumulation of a-synuclein (a-syn) into proteinaceous aggregates is a cellular hallmark of these diseases. LÄS MER

3. 12. Investigation of alpha-synuclein pathology in Parkinson's disease

   Författare :Wen Li; Neural plasticitet och reparation; []
   Nyckelord :Parkinson s disease; alpha-synuclein; mitochondria; propagation;

   Sammanfattning : AbstractParkinson's disease (PD) is one of the most common neurodegenerative diseases in humans. It is a slowly progressing neurological disorder exhibiting major symptoms including resting tremor, rigidity, bradykinesia and postural instability. LÄS MER

4. 13. α-Synuclein Fibril Formation and the Effects of Lipid Membranes

   Författare :Ricardo Gaspar; Fysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; alpha-synuclein; Parkinson s disease; microscopic rate constants; Thioflavin T; ganglioside lipids; Exosomes; protein-lipid co-aggregation; model membranes; monomer-dependent secondary nucleation;

   Sammanfattning : Amyloid protein aggregation results in major disturbances of cellular processes in humans. The most common amyloid-related disorders are Alzheimer´s disease and Parkinson´s disease. Parkinson´s disease is charaterized by the formation of protein-rich aggregates that are deposited in neurons, termed Lewy bodies and Lewy neurites. LÄS MER

5. 14. Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders

   Författare :Therese Fagerqvist; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Michael G Schlossmacher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson´s disease; Lewy body dementia; Oligomer; Monoclonal antibody; Immunotherapy; Reactive aldehydes; Medical Science; Medicinsk vetenskap;

   Sammanfattning : The protein alpha-synuclein (α-synuclein) accumulates in the brain in disorders such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). It is believed that the monomeric form of α-synuclein can adopt a partially folded structure and start to aggregate and form intermediately sized oligomers or protofibrils. LÄS MER

7. 15. NMR studies on lipid-peptide co-aggregation between ganglioside-containing membranes and α-synuclein

   Författare :Simon Fridolf; Fysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; nuclear magnetic resonance spectroscopy; lipid membrane; ganglioside; alpha-synuclein;

   Sammanfattning : This topic of this thesis is how the presence of biomembrane molecules affect the behavior of a protein related to Parkinson’s disease in a simplified (compared to in the cell) model system.Lipids are fat molecules that make up the biological barriers in our body that control transport of essential molecules in and out of the cell and create an environment where membrane proteins can perform their functions. LÄS MER