Sökning: "Synucleinopathies"
Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet Synucleinopathies.
1. Oligodendroglial (dys)function in alpha-synucleinopathies
Sammanfattning : The complexity of a-synucleinopathies, which include multiple system atrophy (MSA) and Parkinson’s disease (PD), is not entirely understood. It is known that pathological accumulation of a-synuclein (a-syn) into proteinaceous aggregates is a cellular hallmark of these diseases. LÄS MER
2. Role of Neuroinflammation in Parkinson's Disease and Related Disorders
Sammanfattning : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. LÄS MER
3. Alpha-synuclein: pathology, peripheral expression, and environmental interactions
Sammanfattning : .... LÄS MER
4. Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies
Sammanfattning : Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesis of Parkinson’s disease and dementia with Lewy bodies, collectively known as α-synucleinopathies. Native α-syn is a monomeric presynaptic protein that can act as a molecular chaperone for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. LÄS MER
5. Development of specific monoclonal antibodies against different forms of alpha-synuclein as diagnostic tools for synucleinopathies
Sammanfattning : Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies(DLB) and multiple system atrophy (MSA), are a group of neurodegenerative disorders characterized by the abnormal accumulation of insoluble alpha-synuclein (α-syn) aggregates in the brain. The detection of α syn pathology has relied vastly on the use of several antibodies, which were mostly generated against different forms of α-syn. LÄS MER