Sökning: "Acute myeloid leukaemia"

Visar resultat 6 - 10 av 20 avhandlingar innehållade orden Acute myeloid leukaemia.

  1. 6. Molecular studies of acute myeloid leukemia and the telomerase reverse transcriptase gene

    Författare :Charlotta Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aacute myeloid leukaemia; telomerase hTERT; cancer cytogenetics; spectral karyotyping; gene expression profiling;

    Sammanfattning : Multiple chromosome rearrangements (MCRs) are detected in approximately 10% of patients with acute myeloid leukemia (AML), and are associated with an adverse prognosis. Comprehensive analysis of the chromosome rearrangements in these complex karyotypes has previously been hampered by the limitations of conventional cytogenetic techniques such as G-banding. LÄS MER

  3. 7. Genetic and epigenetic studies of acute myeloid leukemia and therapeutic possibilities

    Författare :Huthayfa Mujahed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises from immature myeloid progenitors. Consequently, this leads to excessive accumulation of dysfunctional blast cells and lack of normal blood cells. LÄS MER

  4. 8. DNA methylation in T cell leukaemia

    Författare :Maike Bensberg; Colm Nestor; Maria Jenmalm; Sofie Degerman; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. LÄS MER

  5. 9. Uncovering biomarkers and molecular heterogeneity of complex diseases : Utilizing the power of Data Science

    Författare :Sara Younes; Linda Holmfeldt; Jan Komoroski; Aedin Culhane; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complex Disease; Cancer; Autoimmune diseases; Acute Myeloid Leukemia; Systemic Lupus Erythematosus; Bioinformatics; Machine Learning; Data Science; Statistical Analysis; Bioinformatics; Bioinformatik; Computer Science; Datavetenskap;

    Sammanfattning : Uncovering causal drivers of complex diseases is yet a difficult challenge. Unlike single-gene disorders complex diseases are heterogeneous and are caused by a combination of genetic, environmental, and lifestyle factors which complicates the identification of patient subgroups and the disease causal drivers. LÄS MER

  7. 10. Systemic lupus erythematosus (SLE) and cancer : epidemiological and immunohistochemical studies on SLE patients with malignant lymphoma or myeloid leukaemia

    Författare :Björn Lövström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignancy as a cause of death was reported in occasional SLE patients, but the question whether patients with SLE have an increased risk of developing cancer compared to the general population has remained unanswered. To address this question, we created a national Swedish SLE cohort from the Hospital Discharge Register where all patients with an SLE diagnosis between 1964 and 1994 were included. LÄS MER