Sökning: "Acetaminophen"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet Acetaminophen.

  1. 1. Pain treatment after surgery With special reference to patient-controlled analgesia, early extubation and the use of paracetamol

    Detta är en avhandling från Stockholm : Repro Print

    Författare :Pia Holmér Pettersson; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acetaminophen; analgesia; patient-controlled; analgesics; day surgery; heart surgery; opioid; ketobemidone; pain measurement; pain; postoperative; paracetamol; postoperative nausea and vomiting; visual analogue scale; Acetaminophen; analgesia; patient-controlled; analgesics; day surgery; heart surgery; opioid; ketobemidone; pain measurement; pain; postoperative; paracetamol; postoperative nausea and vomiting; visual analogue scale;

    Sammanfattning : The introduction of general anaesthesia eliminated pain during surgical operations. After surgery, however, pain and postoperative nausea and vomiting (PONV) have remained a persistent problem for many patients. The need for analgesics varies widely among patients, therefore standardised treatment protocols are often insufficient pain treatment. LÄS MER

  2. 2. Bioactive Lipids in Nociception

    Detta är en avhandling från Clinical Chemistry and Pharmacology, Dept of Laboratory Medicine

    Författare :Anna Ermund; Lunds universitet.; Lund University.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cannabinoids; Anandamide; AM404; 2-Arachidonoylglycerol; Acetaminophen; Cyclooxygenase; Nocicieption; TRPV1;

    Sammanfattning : This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. LÄS MER

  3. 3. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Sarah Piel; Lunds universitet.; Lund University.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

    Sammanfattning : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. LÄS MER

  4. 4. Risk factors for the development of chronic renal failure : Epidemiological studies on the role of analgesic use, occupational exposures and socioeconomic background

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Sciences ; Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics

    Författare :Michael Fored; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney failure; chronic; Analgesics; non-narcotic; Case-control study; Risk factors; Acetaminophen; Paracetamol; Aspirin; Acetylsalicylic acid; Bias epidemiology ; Education; Socioeconomic factors; occupations; Occupational exposure; Solvents; Metals; heavy; Silicon compounds; Dust.;

    Sammanfattning : Chronic renal failure is a severe condition that reduces life expectancy and typically progresses to end-stage renal disease and a need for renal replacement therapy. In a large proportion of cases, chronic renal failure evolves from known renal or systemic diseases, but in some cases the pathogenesis remains unknown. LÄS MER

  5. 5. Cellular and molecular mechanisms of ischemic brain damage in hyperglycemic rats

    Detta är en avhandling från Experimental Brain Research, Lund University

    Författare :Hiroyuki Uchino; Lunds universitet.; Lund University.; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Reperfusion injury; Mitochondria; Permeability transition; Cyclosporin A; Neurotrophins; Seizures; Brain damage; Acidosis; Hypercapnia; Ischemia; Hyperglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The present study is centered on mechanisms of ischemic brain damage in hyperglycemic animals, and in those in which exaggerated intraischemic acidosis was induced by superimposed hypercapnia in normoglycemic animals. The initial experiments were focussed on the pathophysiology of postischemic seizures. LÄS MER