Sökning: "Aβ40"

Visar resultat 6 - 10 av 18 avhandlingar innehållade ordet Aβ40.

  1. 6. Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics

    Författare :Jenna Najar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Alzheimer s disease; Epidemiology; Marital status; Leisure time activity; Menopause; Polygenic risk scores; APOE genotype;

    Sammanfattning : Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers for Alzheimer’s disease (AD). Method: We used population-based samples from the Gothenburg H70 Birth Cohort Studies (H70-studies), the Prospective Population Study of Women (PPSW), and the Mayo Clinic Study of Aging (MCSA 70+ study). LÄS MER

  3. 7. Different types of γ-secretes complexes and their effect on substrate processing

    Författare :Annelie Pamrén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide (Aβ) from the amyloid precursor protein (APP). The γ-secretase complex cleaves APP at two different sites (γ- and ε-sites) generating Aβ-peptides and the APP intracellular domain (AICD). LÄS MER

  4. 8. The Mitochondrial Peptidasome, PreP, relation to Alzheimer Disease

    Författare :Nyosha Alikhani; Elzbieta Glaser; Doron Rapaport; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Amyloid-β (Aβ) is the toxic peptide implicated in the pathogenesis of Alzheimer Disease (AD). Accumulation of Aβ has been shown in brain mitochondria from AD patients and AD mice models. The occurrence of Aβ in the mitochondrial matrix leads to free radical generation and apoptosis in neurons. LÄS MER

  5. 9. BRICHOS - a Novel Anti-Amyloid Chaperone : studies on pro-surfactant protein C

    Författare :Hanna Willander; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Lung surfactant protein C (SP-C) is a 35-residue, transmembrane (TM) peptide that is extremely hydrophobic and lacks known homologous proteins. Due to a high content in Val residues in the α-helical TM part, SP-C can spontaneously convert into β-sheet aggregates. LÄS MER

  7. 10. The interplay between mitochondria-endoplasmic reticulum contacts and Alzheimer’s disease

    Författare :Nuno João Santos Leal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Even though Alzheimer’s disease (AD) was first described more than 100 years ago, we still have no treatment preventing the ongoing neurodegenerative process. Two major pathological hallmarks have been connected to AD: extracellular amyloid plaques (constituted by amyloid β-peptide – Aβ) and neurofibrillary tangles. LÄS MER