Sökning: "[alpha][beta] T cells"

Visar resultat 11 - 15 av 23 avhandlingar innehållade orden [alpha][beta] T cells.

1. 11. Natural and induced idiotype immunity in patients with multiple myeloma

   Författare :Lotta Hansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Myeloma; idiotype; vaccination; GM-CSF; IL-12; clonal B cells; T cell epitopes; signal transduction molecules; activation markers;

   Sammanfattning : There is a great need for development of new treatment alternatives for patients with multiple myeloma (MM). The idiotype (Id) immunoglobulin (Ig) expressed by the myeloma B cell clone might be regarded as a tumor specific antigen and as such a target for immunotherapy. LÄS MER

3. 12. The role of interferons in the resistance to infection with Chlamydia pneumoniae

   Författare :Christian Trumstedt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Chlamydia pneumoniae is an obligate intracellular bacterial pathogen that infects the respiratory tract in human. IFN-gamma is an essential cytokine for the immune response triggered to limit infection with C. pneumoniae. C. LÄS MER

4. 13. Autoimmune and innate inflammation in the nervous system : neurotrophin production and impact on neuronal survival

   Författare :Cecilia Lundberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurodegeneration; autoimmunity; neurotrophin; motoneuron; cytokine; axotomy;

   Sammanfattning : The occurrence of a continuous immune surveillance in the central nervous system (CNS) is a fairly recent finding. For long the CNS was considered an immune privileged organ, with the blood-brain barrier constituting an effective barrier against blood-derived molecules and cells. LÄS MER

5. 14. Immunogenetic markers in immune mediated diseases

   Författare :Liene Nikitina-Zake; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HLA; MICA; TNFA; TNFa; KIR; CIN; cervical cancer; juvenile arthritis; MCTD; type I diabetes mellitus;

   Sammanfattning : The aim of this thesis was to study HLA class II markers, as well as other - MHC and non MHC genes in different immune - mediated diseases, namely, cervical intraepithelial neoplasia (CIN), cervical cancer, juvenile idiopathic arthritis (JIA), mixed connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM). HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune-mediated diseases due to the function of the molecules these genes encode. LÄS MER

7. 15. Viral vectors, in innate and adaptive immunity

   Författare :Tanja I Näslund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Recombinant viral vectors and DNA vectors induce strong immune responses in animal models. However, in clinical trials, the generation of immune responses is less robust, suggesting that further optimization and a deeper understanding of nucleic acid-based vaccines are required. LÄS MER