Sökning: "ADAM10"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet ADAM10.
1. α-Secretase processing of the Alzheimer amyloid-β precursor protein and its homolog APLP2
Sammanfattning : The amyloid-β precursor protein (APP) has been widely studied due to its role in Alzheimer´s disease (AD). When APP is sequentially cleaved by β- and γ-secretase, amyloid-β (Aβ) is formed. Aβ is prone to aggregate and is toxic to neurons. LÄS MER
2. The amyloid-β precursor protein (APP)-binding protein Fe65 and APP processing
Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of neurotoxic amyloid-β (Aβ) peptide. Aβ is generated by sequential cleavage of the amyloid-β precursor protein (APP) by β- and then γ-secretase. LÄS MER
3. Processing of the APP family by the α-secretases ADAM10 and TACE
Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by formation of amyloid plaques in the brain. The major constituent of these plaques is the hydrophobic peptide Aβ. Aβ accumulation is considered to be the main cause of the pathology seen in AD brains. LÄS MER
4. Losing connections in Alzheimer disease : the amyloid precursor protein processing machinery at the synapse
Sammanfattning : Synaptic degeneration is one of the earliest characteristics of Alzheimer disease (AD). The amyloid β-peptide (Aβ) plays a critical role in the pathology of AD and therefore thorough understanding of its production and functions is of outmost importance. LÄS MER
5. Models of the lung tissue microenvironment for studies of human myeloid cell function
Sammanfattning : Studies of the immune system requires knowledge concerning not only the perturbating event itself, i.e. specific microorganisms, and how it interacts with immune cells but also how it functions in its natural environment – tissues. LÄS MER