Sökning: "water motif"

Visar resultat 21 - 25 av 25 avhandlingar innehållade orden water motif.

  1. 21. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function

    Författare :Pierre Matricon; Jens Carlsson; Bjørn Olav Brandsdal; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Dynamics Simulations; Free Energy Perturbation; Ligand Binding; Fragment-Based Lead Discovery; Molecular Docking Screens; Homology Modeling; GPCR Activation Mechanism; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. LÄS MER

  3. 22. Synthesis of hemes found in heme-copper oxidases of Bacillus subtilis

    Författare :Mimmi Throne-Holst; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Biologi; Biology; heme biosynthesis; respiratory oxidase; cytochrome; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : The last step of aerobic respiration, the reduction of dioxygen to water, is catalysed by terminal oxidases. These oxidases can be divided into two unrelated families, the heme-copper oxidases and the cytochrome bd-type oxidases. These enzymes contain two or more heme molecules as prosthetic groups. LÄS MER

  4. 23. Biomolecular interactions at model interfaces : a self-assembled monolayer approach

    Författare :Sofia Svedhem; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The overall aim of this thesis has been to explore the use of self-assembled monolayers (SAMs) in model studies of biomolecular binding at interfaces. Molecular details of interfaces are difficult to address experimentally, and in spite of the fact that interactions in the living system commonly occur at interfaces, e.g. LÄS MER

  5. 24. Amine transaminase: Process development aspects for chiral amine synthesis

    Författare :Tim Börner; Bioteknik; []
    Nyckelord :;

    Sammanfattning : Many modern drugs contain chiral amine moieties and the need for more efficient processes to synthesize these amines in high optical purity and concentration are greatly demanded by the fine chemical and pharma industry. Amine transaminases (ATA) allow for the direct asymmetric synthesis of optically pure amines from ketone substrates. LÄS MER

  7. 25. Identification, cloning and characterization of the p53 induced gene human Wig-1

    Författare :Fredrik Hellborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor p53 is a transcription factor that responds to various kinds of cellular stress. In respons to the sensed stress it is able to induces cell cycle arrest and apoptosis. In order to achieve these effects it transactivates target genes. LÄS MER