Sökning: "Molecular Docking Screens"

Hittade 3 avhandlingar innehållade orden Molecular Docking Screens.

  1. 1. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function

    Författare :Pierre Matricon; Jens Carlsson; Bjørn Olav Brandsdal; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Dynamics Simulations; Free Energy Perturbation; Ligand Binding; Fragment-Based Lead Discovery; Molecular Docking Screens; Homology Modeling; GPCR Activation Mechanism; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. LÄS MER

  3. 2. Membrane Stress and the Role of GYF Domain Proteins

    Författare :Alexander Georgiev; Åke Wieslander; Hana Sychrova; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SYH1; SMY2; YPT6; RIC1; MYR1; processing bodies; vesicular trafficking; lipid bilayer; budding yeast; GYF; membrane stress; mRNA decay; Saccharomyces cerevisiae; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Intracellular membrane trafficking is regulated by a large number of protein complexes and lipids. Blocking of trafficking disrupts normal membrane dynamics and causes membrane stress. LÄS MER

  4. 3. The impact of GPCR structures on understanding receptor function and ligand binding

    Författare :Anirudh Ranganathan; Jens Carlsson; György Keserű; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : G protein-coupled receptors (GPCRs) form the largest superfamily of eukaryotic membrane proteins and are responsible for the action of nearly 30% of all marketed drugs. For a long period, efforts to study these receptors were limited by the paucity of atomic-resolution structural information. LÄS MER