Sökning: "vascular remodelling"
Visar resultat 31 - 35 av 40 avhandlingar innehållade orden vascular remodelling.
31. Cardiovascular and metabolic effects of endothelins in man : an experimental and clinical study
Sammanfattning : Increased plasma concentrations of endothelin-1 (ET-1) and of its propeptide big endothelin-1 have been reported in diseases associated with endothelial dysfunction, cardiovascular remodelling and insulin resistance. In this thesis, we studied the hemodynamic effects of big ET-1 in healthy humans focusing on the mechanisms of the effects (study I-IV). LÄS MER
32. Human ovulation. Studies on collagens, gelatinases and tissue inhibitors of metalloproteinases
Sammanfattning : Ovulation is a highly regulated process, which involves the degradation and rupture of healthy tissue of the ovarian follicle and the extrusion of a fertilizable oocyte. This unique biological process is initiated by the LH-surge, which induces major vascular changes and remodelling of the extracellular matrix (ECM) in and around the follicle. LÄS MER
33. Genetic and phenotypic discordance in cardiometabolic diseases
Sammanfattning : Cardiometabolic conditions such as obesity and type 2 diabetes (T2D) are among the first causes of death globally, and the number of people affected is rapidly increasing. Both conditions are intricately connected and are associated with many life-threatening cardiovascular disease (CVD). LÄS MER
34. Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity
Sammanfattning : Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing and potential new therapies for asthma. LÄS MER
35. Extracellular matrix in atherosclerotic plaques: its role in plaque stability
Sammanfattning : Atherosclerosis is a systemic disease affecting the large arteries caused by the accumulation of lipids in the vessel wall. Cardiovascular disease due to atherosclerosis is today the most common cause of death globally through its end consequences: myocardial infarctions and stroke. LÄS MER