Sökning: "big ET-1"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden big ET-1.

  1. 1. Cardiovascular and metabolic effects of endothelins in man : an experimental and clinical study

    Författare :Astrid Ottosson-Seeberger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :endothelin-1; big ET-1; C-terminal big ET-1 22-3 8 fragment; hemodynamic; blood flow; fractional extraction; conversion; plasma half-life; end-stage renal failure; ischemic heart disease; hemodialysis; high-flux membrane; glucose uptake; insulin sensitivity;

    Sammanfattning : Increased plasma concentrations of endothelin-1 (ET-1) and of its propeptide big endothelin-1 have been reported in diseases associated with endothelial dysfunction, cardiovascular remodelling and insulin resistance. In this thesis, we studied the hemodynamic effects of big ET-1 in healthy humans focusing on the mechanisms of the effects (study I-IV). LÄS MER

  3. 2. The importance of endothelin-1 for vascular function in patients with atherosclerosis and healthy controls

    Författare :Felix Böhm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; atherosclerosis; blood flow; circulation; coronary disease; endothelin; endothelium; kidney; liver; nitric oxide; patients; receptors; vasoconstriction.;

    Sammanfattning : Background: Atherosclerosis is associated with endothelial dysfunction, which is an early sign with prognostic implications in patients with coronary artery disease. Atherosclerosis is also associated with enhanced expression of the vasoconstrictor peptide endothelin-1 (ET-1). LÄS MER

  4. 3. Endothelin and endothelin receptors in human pregnancy and delivery

    Författare :Kerstin Wolff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; endothelin receptor; human; pregnancy; preeclampsia; delivery;

    Sammanfattning : Background: Endothelin-1 (ET-1) is a 21-amino acid peptide, first described by Yanagisawa et al in 1988. It is one of the most potent constrictors of smooth muscle cells identified to date. LÄS MER

  5. 4. Endothelin and the regulation of peripheral and uteroplacental vascular tone during pregnancy

    Författare :Gunilla Ajne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; pregnancy; uteroplacental blood flow; peripheral resistance; endothelin receptors;

    Sammanfattning : The mechanism behind the vascular adaptation during pregnancy is poorly understood. The fall in peripheral resistance, particularly in the uterine vasculature, is crucial for sufficient increase in uteroplacental blood flow and thereby for normal fetal growth and development. LÄS MER

  7. 5. Endothelial function and dysfunction in coronary artery bypass grafting

    Författare :Ulf Lockowandt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CABG; Endothelin; Endothelin-blockers; endothelium; lactate; off-pump CABG; prostacyclin; radial artery; unstable angina pectoris;

    Sammanfattning : The integrity of the endothelium is of importance for short- and long-term results following coronary artery bypass grafting (CABG). In this thesis different factors of the endothelial role in the regulation of vascular tone in relation to various current aspects of CABG have been investigated. LÄS MER