Sökning: "tumour targeting"

Visar resultat 1 - 5 av 60 avhandlingar innehållade orden tumour targeting.

  1. 1. Tumour Targeting Using Radiolabelled EGF Conjugates Preclinical Studies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Åsa Liljegren Sundberg; Uppsala universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; MEDICINE Physiology and pharmacology Radiological research Radiation biology; MEDICIN Fysiologi och farmakologi Radiologisk forskning Strålningsbiologi;

    Sammanfattning : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. LÄS MER

  2. 2. Two-Step Targeting for Effective Radionuclide Therapy Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Amelie Fondell; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide; Auger electrons; liposomes; targeting; tumour therapy; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. LÄS MER

  3. 3. Aspects of Tumour Targeting Preclinical Studies on Human Malignant Cells in vitro

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Maria Dahlström Wester; Linköpings universitet.; Linköpings universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : Exclusive eradication of tumour cells causing minimal damage to healthy tissue, a concept referred to as targeting, is an interesting approach to improve the outcome for patients afflicted with cancer.The general aim of this thesis was to highlighten aspects that could be of importance in developing novel treatment regimens based on specific targeting of tumour cells. LÄS MER

  4. 4. Radioimmunotherapy in Experimental Head and Neck Squamous Cell Carcinoma Tumour-targeting in vitro and in vivo

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Junping Cheng; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Otorhinolaryngology; squamous cell carcinoma; radioimmunotherapy; cell line; tumour targeting; radionuclide; nude mice; Otorhinolaryngologi; MEDICINE Surgery Otorhinolaryngology; MEDICIN Kirurgi Otorhinolaryngologi;

    Sammanfattning : Radioimmunotherapy (RIT) has been shown to be a practicable way to treat head and neck squamous cell carcinoma. A specific antibody recognizes the charasteristic structure of tumour cells when loaded with cytotoxic agents (toxins, drugs, radionuclides, etc). LÄS MER

  5. 5. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy Preclinical Studies on Head and Neck Cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Marika Nestor; Uppsala universitet.; [2006]
    Nyckelord :Otorhinolaryngology; antibodies; radionuclide targeting; tumour targeting; therapy; diagnostics; immuno-PET; head and neck squamous cell carcinoma; Otorhinolaryngologi;

    Sammanfattning : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. LÄS MER