Sökning: "tumour targeting"
Visar resultat 16 - 20 av 80 avhandlingar innehållade orden tumour targeting.
16. Indirect Radiohalogenation of Targeting Proteins : Labelling Chemistry and Biological Characterisation
Sammanfattning : In about half of all newly diagnosed cancer cases, conventional treatment is not adequately curative, mainly due to the failure of conventional techniques to find and kill residual cells and metastases, which might consist of only a few malignant cells, without causing unacceptable complications to healthy tissue. To solve the problem a more selective delivery of cytotoxic substances to tumour cells is needed. LÄS MER
17. Cellular Studies of HER-family Specific Affibody Molecules
Sammanfattning : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. LÄS MER
18. Targeting Myc-driven tumours - BETing on ATR
Sammanfattning : Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and it is found to be deregulated in more than 70% of the tumours. LÄS MER
19. Functional studies of the Sro yeast homologues of the Drosophila lethal (2) giant larvae tumor suppressor genes
Sammanfattning : .... LÄS MER
20. Specific targeting of antigen-presenting cells for immunotherapy
Sammanfattning : Immunotherapy, which involves strategies to activate, enhance or redirect immune responses to achieve long-lasting immunity, has the potential to play an important role in the treatment of a variety of diseases. This thesis, based on four original papers, highlights different approaches to modulate immune responses by specific targeting of antigen-presenting cells. LÄS MER