Sökning: "trimethyltin"

Hittade 5 avhandlingar innehållade ordet trimethyltin.

1. 1. Heavy metal neurotoxicity : on trimethyltin-, methylmercury- and cadmium-induced disturbances of neurotransmitter systems and neurotrophins

   Författare :Helena Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurotoxicity; trimethyltin; methylmercury; cadmium; development; GFAP; GABA; noradrenalin; BDNF; c-fos; hsp70; glial glutamate transporter;

   Sammanfattning : Organic and inorganic metal compounds produced by human activities often reach the environment where they are associated with a plethora of potential health hazards. Of particular concern is the risk for CNS disturbances during development or in the adult. LÄS MER

3. 2. Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole

   Författare :Malin Björk; Spiros Grivas; Christopher A. Ramsden; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aminoimidazoazaarenes; thienomethyleneimidazolinones; imidazo[4; 5b]pyridines; Friedländer; imidazo[4; 5-e]-2; 1; 3-benzoselenadiazoles; 2-aminobenzimidazoles. palladium catalyzed coupling reactions.;

   Sammanfattning : The chemistry developed in this thesis can be divided into two parts. The first part, which is the major part of the thesis, contains syntheses towards analogues to mutagenic heterocyclic amines found in e.g. meat fried at high temperatures. LÄS MER

4. 3. Molecular mechanisms of metal toxicity in neuronal cells

   Författare :Annamaria Rossi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Modification of signal transduction by toxic agents can affect cell metabolism and physiological activity, impair cell capacity to adequately respond to hormones and growth stimuli and consequently compromise cell survival. This thesis describes studies on the interactions between toxic metals, at concentrations comparable to environmental exposure, and Ca2+ signalling in neuronal cells. LÄS MER

5. 4. Distribution and pathophysiological role of amyloid precursor protein and presenilin 1 : characterization in rats and in vitro studies on the pathogenic arctic mutation

   Författare :Camilla Nilsberth; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer's disease is the most common form of dementia that presents a growing dilemma worldwide. Alzheimer's disease is neuropathologically characterized by cerebral atrophy accompanied by deposition of senile plaques and neurofibrillary tangles. LÄS MER

7. 5. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

   Författare :Beata Kostyszyn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. LÄS MER