Sökning: "transferrin"

Visar resultat 11 - 15 av 64 avhandlingar innehållade ordet transferrin.

1. 11. Enhancing the therapeutic effect of biological drugs with protein engineering : Focusing on pre-clinical Alzheimer’s disease therapy

   Författare :Fadi Rofo; Greta Hultqvist; Stina Syvänen; Sara Mangsbo; Joy Zuchero; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloid-beta; blood-brain barrier; transferrin receptor; protein-drugs; multivalent-bispecific antibodies;

   Sammanfattning : Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s disease (AD). The soluble Aβ aggregates (oligomers and protofibrils) have shown to be the most harmful species. Hence, targeting these aggregates can be of therapeutic potential. LÄS MER

3. 12. The dynamics of red blood cells and iron status during infancy

   Författare :Marie Larsson; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Barnreferensintervall; Röda blodkroppar; Erytrocyter; Extremt för tidig födsel; Erytropoes; Klinisk kemi; Järnstatus; Ferritin; sTfR; Neonatologi; Pediatrik; Fetal tillväxthämning; Referensintervall; Pediatric reference intervals; Reference limits; Extremely preterm birth; Fetal growth restriction; Clinical chemistry; Iron status; Red blood cells; Erythrocyte; Transfusion; Ferritin; sTfR; Hemoglobin; Neonatal; Reference intervals; Umbilical cord blood; Infancy; Iron deficiency; Anemia; Acute phase response; soluble Transferrin receptor; Neonatal intensive care; Erythropoiesis; Birth; Infant;

   Sammanfattning : Red blood cell (RBC) and iron status biomarkers are commonly used in clinical diagnostics. However, interpretations of infant test results are inherently challenging. LÄS MER

4. 13. Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG

   Författare :Jonas P Bergström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alcohol use and abuse is a major social and economic problem in many societies. Carbohydrate-deficient transferrin (CDT) is a widely used and highly specific biochemical alcohol marker of prolonged alcohol abuse. LÄS MER

5. 14. New markers of alcohol consumption : development and evaluation of the clinical use of carbohydrate-deficient transferrin in serum and 5-hydroxytryptophol in urine

   Författare :Annette Voltaire Carlsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alcohol drinking; 5-hydrogxytryptophol; 5-hydroxyindole-3-acetic acid; urine; human; ;

   Sammanfattning : Treatment of alcohol dependence and evaluation of treatment and research programs are often based on self-reports of the patients. Since the alcohol consumption pattern does not always relate to the reported behaviour there is a need for validation by reliable biochemical markers. LÄS MER

7. 15. Cadmium exposure and iron status

   Författare :Agneta Åkesson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :environmental exposure; biological monitoring; bioavailability; pregnancy; cadmium; iron deficiency; hemochromatosis; dietary intake; soluble transferrin receptor; serum ferritin;

   Sammanfattning : People are exposed to cadmium, a ubiquitous toxic metal, mainly via basic foods such as cereals and vegetables. Cadmium accumulates in the kidney, and renal tubular damage is considered the critical effect. Recently, association with osteoporosis at environmental exposure levels was indicated. LÄS MER