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Visar resultat 1 - 5 av 17 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study

   Författare :Sara Kinhult; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; endothelin; onkologi; Cytologi; cancer; von Willebrand factor; thrombomodulin; lipoperoxidation; probucol; low-molecular weight heparin; scanning electron microscopy; 5-fluorouracil; endothelium;

   Sammanfattning : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. LÄS MER

3. 2. Hand-arm vibration injury - Neurosensory, vascular manifestations, severity grading, and serum biomarkers

   Författare :Eva Tekavec; Arbetsrelaterade besvär i rörelseorganen; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hand-arm vibration injury; Hand-arm vibration syndrome HAVS ; Raynaud s phenomenon; Nerve injury; Seum biomarkers; Vibration perception thresholds; Griffin scores; Stockholm work shop scale; International consensus criteria; Calcitonin gene related peptide; Thrombomodulin; Heat shock protein 27; Caspase 3; ICAM-1; MCP-1; von Willebrand factor; cold intolerance; Small fibre neuropathy; Hand-arm vibrations skada; Nerv skada; Köldintolerans;

   Sammanfattning : .... LÄS MER

4. 3. Genetics, epigenetics and functional mechanisms in inherited corneal and retinal dystrophies

   Författare :Ida Maria Westin; Irina Golovleva; Berit Byström; Marie Burstedt; Ola Sandgren; Sudha Iyengar; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Epigenetics; Splicing; Methylation; Ophtalmology; FECD; Stargardt; Retinitis pigmentosa; ABCA4; EYS; TCF4; F5; THBD; Coagulation factor V; Thrombomodulin; medicinsk genetik; Medical Genetics;

   Sammanfattning : Inherited eye disorders (IED) are groups of genetically and clinically heterogenous conditions affecting different tissues in the eye. IED are most often progressive with reduced vision or legal blindness as outcome. LÄS MER

5. 4. Modifying xenogeneic immune recognition and engraftment by genetic engineering

   Författare :Zhong He; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Xenotransplantation; gene therapy; gene transfer; endothelium; promoters; monocytes; NK cells; alpha-Gal; lentivirus vectors; pancreatic islets;

   Sammanfattning : Transplantation using xenogenic organs, tissues and cells (i.e. xenotransplantation) is a potential solution to the shortage of those from human sources. Vascular endothelial cells (ECs) are the most immediate barrier between the xenogeneic donor organ and the host defense systems. LÄS MER

7. 5. Determinants of adverse events during oral anticoagulant treatment

   Författare :Marcus Lind; Jan-Håkan Jansson; Lars Johansson; Kurt Boman; Sam Schulman; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral anticoagulants; warfarin; mortality; bleeding; biomarkers; Medicine; medicin;

   Sammanfattning : Treament with oral anticoagulation is highly effective in reducing the burden of thromboembolic complications in several clinical conditions. The number of patients receiving oral anticoagulation is growing steadily. InSwedenabout 1.5 percent of the population receives treatment. LÄS MER