Sökning: "alpha-Gal"

Hittade 3 avhandlingar innehållade ordet alpha-Gal.

  1. 1. Modifying xenogeneic immune recognition and engraftment by genetic engineering

    Författare :Zhong He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Xenotransplantation; gene therapy; gene transfer; endothelium; promoters; monocytes; NK cells; alpha-Gal; lentivirus vectors; pancreatic islets;

    Sammanfattning : Transplantation using xenogenic organs, tissues and cells (i.e. xenotransplantation) is a potential solution to the shortage of those from human sources. Vascular endothelial cells (ECs) are the most immediate barrier between the xenogeneic donor organ and the host defense systems. LÄS MER

  3. 2. Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers

    Författare :Jining Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human allotransplantation is nowadays the generally accepted treatment of choice for several illnesses leading to organ failure. A major problem facing clinical organ transplantation is the lack of human donor organs and tissues. Xenotransplantation from pig to man is considered a plausible solution to this problem. LÄS MER

  4. 3. In vitro models of xenograft rejection : studies on leukocyte-endothelial cell interactions

    Författare :Cecilia Ehrnfelt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Xenotransplantation; endothelium; neutrophils; monocytes; NK cells; a-Gal; antibodies; porcine islets; MCP-1;

    Sammanfattning : Xenotransplantation is the transplantation of cells, tissues or organs between different species and is a potential alternative to allotransplantation because of the lack of human donors. The pig is believed to be a suitable donor-species to man for medical, technical, financial and ethical reasons. LÄS MER