Sökning: "probucol"

Hittade 4 avhandlingar innehållade ordet probucol.

  1. 1. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study

    Författare :Sara Kinhult; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; endothelin; onkologi; Cytologi; cancer; von Willebrand factor; thrombomodulin; lipoperoxidation; probucol; low-molecular weight heparin; scanning electron microscopy; 5-fluorouracil; endothelium;

    Sammanfattning : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. LÄS MER

  3. 2. Uptake, induction and distribution of ubiquinone and a-tocopherol

    Författare :Yiyi Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ubiquinone (UQ) and a-tocopherol are the major lipid-soluble antioxidants in animal tissues. Appropriate amounts of these lipids have to be present in tissues and subcellular membranes. Uptake from the diet was investigated and it was also analyzed to which extent the tissue amount may be increased by induction of biosynthesis. LÄS MER

  4. 3. Tumor necrosis factor-a in atherosclerosis

    Författare :Stefan Jovinge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; oxidized low-density lipoprotein; monocytes; tumor necrosis factor-a; cytokinesis; ets-l; matrix metalloproteinases; apoptosis; glucose metabolism; insulin resistance; myocardial infarction;

    Sammanfattning : The presence of inflammatory cells is prominent at all phases of the atherosclerotic process leaving no doubt that the inflammation is of central importance in atherosclerosis. The recruitment of inflammatory cells into the vessel wall is therefore a key event in early lesion formation. LÄS MER

  5. 4. Inflammatory transcription factors in atherosclerosis

    Författare :Wolfgang Dichtl; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : Transcription factors such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) and peroxisome proliferator-activated receptors (PPARs) may play important roles in atherogenesis, by regulating chronic subclinical vascular inflammation. In the first study, we showed that VLDL activates the proinflammatory transcription factor NF-kB in endothelial cells both in vitro and in vivo. LÄS MER