Sökning: "spray-dried solid dispersion"

Hittade 2 avhandlingar innehållade orden spray-dried solid dispersion.

1. 1. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs

   Författare :Khadijah Edueng; Christel Bergström; Denny Mahlin; Michael Hageman; Uppsala universitet; []
   Nyckelord :Amorphous formulation; crystallisation; supersaturation; glass-forming ability; physical stability; glass stability; spray-dried solid dispersion; dissolution; promiscuous glass former; poorly-soluble drug; solid-to-solid; solution-mediated; particle-associated; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. LÄS MER

3. 2. Phase Transformations in Solid Pharmaceutical Materials Studied by AFM, ESCA, DSC and SAXS

   Författare :Denny Mahlin; Göran Alderborn; Sven Engström; Duncan Q M Craig; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; polymer; lipid; lactose; phase transformation; phase formation; crystallisation; AFM; X-ray diffraction; ESCA; DSC; solid dispersion; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi;

   Sammanfattning : Mixing excipients is a common way to produce pharmaceutical materials with suitable properties for drug formulation. An understanding of the basic mechanisms involved in the formation and transformation of the structures of solid state mixtures is crucial if one is to be able to produce materials with the desired properties in a reliable way. LÄS MER