Sökning: "supersaturation"

Visar resultat 1 - 5 av 54 avhandlingar innehållade ordet supersaturation.

  1. 1. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs

    Författare :Khadijah Edueng; Christel Bergström; Denny Mahlin; Michael Hageman; Uppsala universitet; []
    Nyckelord :Amorphous formulation; crystallisation; supersaturation; glass-forming ability; physical stability; glass stability; spray-dried solid dispersion; dissolution; promiscuous glass former; poorly-soluble drug; solid-to-solid; solution-mediated; particle-associated; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. LÄS MER

  2. 2. Recovery of Scandium using Antisolvent Crystallization in the Valorization of Scandium-containing Waste Streams

    Författare :Edward Peters; Kerstin Forsberg; Michael Svärd; Jens-Petter Andreassen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antisolvent crystallization; ammonium scandium hexafluoride; ammonium metal fluorides; phase equilibria; solubility; supersaturation; seeding; agitation mechanism; crystal size distribution; morphology; Chemical Engineering; Kemiteknik;

    Sammanfattning : Scandium is widely dispersed in the earth’s crust and is rarely concentrated in ores, and a viable option to guarantee a secure supply of scandium is to recover the metal from waste streams of other mining and metallurgical facilities. The valorization of such streams to recover metals of value is a prerequisite to alleviate the global shortages of scandium and other rare earth elements. LÄS MER

  3. 3. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System

    Författare :Caroline Alvebratt; Christel Anna Sofia Bergström; Maria Strömme; Caitriona O'Driscoll; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amorphous solid dispersion; coadministration; digestion; dissolution; drug absorption; enabling formulation; in vitro assay; lipid-based formulation; mesoporous carrier; supersaturation; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. LÄS MER

  4. 4. Molecular investigations of atmospherically relevant interface processes: ice formation and water accommodation on ice and organic surfaces

    Författare :Xiangrui Kong; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; atmosphere; kinetics; Environmental molecular beam; ice nucleation; supersaturation; accommodation coefficient; phase transition; alcohols; green chemistry;

    Sammanfattning : Clouds and aerosols play important roles in the climate system by affecting on atmospheric chemistry, the radiation budget of the atmosphere, and the water cycle including the formation of precipitation. Climate models with predictive power require quantitative descriptions of aerosols and clouds, but several key processes remain to be fully understood. LÄS MER

  5. 5. In vitro-solubility and supersaturation behavior of supersaturating drug delivery systems

    Författare :Amani AlHayali; Sitaram P. Velaga; Sandra Klein; Luleå tekniska universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Health Science; Hälsovetenskap;

    Sammanfattning : The development of new pharmaceutical products has been challenged by the growing number of poorly water-soluble drugs, which often lead to suboptimal bioavailability. Various approaches, such as the use of amor-phous solid dispersions and cocrystals, have been used to improve the solu-bility, and subsequent bioavailability, of these drug molecules. LÄS MER