Sökning: "smooth muscle cells"

Visar resultat 31 - 35 av 274 avhandlingar innehållade orden smooth muscle cells.

  1. 31. Mechanosensitive transcriptional regulation of gene expression in smooth muscle. Implications for health and disease

    Författare :Fatima Daoud; Molekylär kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; smooth muscle cell; phenotypic modulation; Yap Taz; MRTFA; hypertension; atherosclerosis;

    Sammanfattning : Smooth muscle participates in forming the wall of hollow organs, tracts, and blood vessels. Therefore, it plays a critical role in mediating vital functions in the body including regulation of blood pressure. LÄS MER

  3. 32. The role of smooth muscle cells in calcification of atherosclerotic plaques

    Författare :Till Seime; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but responsible mechanisms and its contribution to the risk of clinical events remain unclear. Formation of highly mineralized extracellular matrix (ECM) leads to progressive aortic valve stenosis (AVS) and has been identified as a surrogate marker for atherosclerotic disease burden. LÄS MER

  4. 33. Developmental regulation of smooth muscle contraction in the urinary bladder

    Författare :Mari Ekman; Cellulär biomekanik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; newborn; Rho-kinase; cellular signaling; muscarinic receptors; calcium sensitivity; protein kinase C; non-muscle myosin; myosin light chain phosphatase;

    Sammanfattning : Smooth muscle cells in the urinary bladder are involved in the control of urine filling and emptying. We have used mice to study the contractile regulation of urinary bladder smooth muscle during the fetal period. LÄS MER

  5. 34. Identification and characterization of new mechanisms in cardiovascular estrogen signaling

    Författare :Anders Holm; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endothelial cells; vascular smooth muscle cells; estrogen; GPR30 GPER1; inflammation; calcium; neovascularization; microtubule;

    Sammanfattning : Women before menopause are protected from cardiovascular disease compared to age-matched men through mechanisms associated with the female sex hormone estrogen. There are three known estrogen receptors named ERα, ERβ and GPR30/GPER1, which are all three receptors are expressed in the cardiovascular system. LÄS MER

  7. 35. Development of Methods to Investigate Pulmonary Arterial Smooth Muscle Cells under Hypoxia

    Författare :Joel Wahl; Kerstin Ramser; Mikael Sjödahl; Fredrik Nikolajeff; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Experimental Mechanics; Experimentell mekanik;

    Sammanfattning : Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to localized alveolarhypoxia that is intrinsic to the pulmonary circulation. By hypoxia-induced contractionof pulmonary arterial smooth muscle cells (PASMCs), the pulmonary capillary bloodflow is redirected to alveolar areas of high oxygen partial pressure, thus maintaining theventilation-perfusion ratio. LÄS MER