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Visar resultat 21 - 25 av 84 avhandlingar som matchar ovanstående sökkriterier.

1. 21. Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-1

   Författare :Jenny Adrian Meredith; Bertil Samuelsson; Ulf Ellervik; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes the synthesis of molecules designed for inhibition of two aspartic proteases, viral HIV-1 PR and human BACE-1. It also reports on the structure activity relationships of the targeted enzyme inhibitors. It is estimated that currently 33 million people are infected with HIV, the causative agent of AIDS. LÄS MER

3. 22. Immune deterioration in HIV-1 and HIV-2 infection with a focus on CD8 T cell exhaustion

   Författare :Lydia Scharf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Thanks to the development of antiretroviral treatment (ART), human immunodeficiency virus (HIV) infection is now considered a chronic infection rather than the death sentence it used to be. Despite constant expansion and improvement of treatment options, even optimal therapy cannot prevent the impact of HIV on the human immune system. LÄS MER

4. 23. Ligand-induced structural changes in HIV-1 envelope glycoprotein

   Författare :Selina Poon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1;

   Sammanfattning : The first step in HIV-1 entry is the interaction between viral envelope glycoprotein gp120 and CD4 receptor on permissive host cells. The interaction initiates a series of sequential conformational rearrangements that exposes epitopes involved in interaction with co-receptors. LÄS MER

5. 24. Welander distal myopathy : clinical and genetic studies

   Författare :Gabrielle Åhlberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Welander distal myopathy; neurogenic component; rimmed vacuoles; linkage; chromosome 2p13; candidate genes; common founder; homozygous form; variable clinical expression;

   Sammanfattning : Distal myopathies are a group of muscular disorders described in many countries with different inheritance patterns and variable progression rates. Welander distal myopathy (WDM) is characterised by autosomal dominant inheritance, late onset and distal distribution of muscular weakness. Most cases originate from the middle parts of Sweden. LÄS MER

7. 25. Neuroinflammation and amyloid-β in early Alzheimer’s disease. Insight into the earliest events using mouse models

   Författare :Megg Gonzales Garcia; Neuroinflammation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; neuroinflammation; microglia; synapses; prion-like;

   Sammanfattning : Alzheimer’s disease (AD) is the leading cause of dementia and most common neurodegenerative disease worldwide, but there currently exists no effective treatment that can stop nor slow the progression of the disease. The current dogma in the field postulates that the appearance of extracellular amyloid-beta (Aβ) plaques, a histopathological hallmark of the disease, is the trigger for downstream, detrimental events, including neuronal loss, extensive neuroinflammation and cognitive decline. LÄS MER