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Visar resultat 16 - 20 av 84 avhandlingar som matchar ovanstående sökkriterier.

  1. 16. Methods for detection of HIV-2/SIV infections

    Författare :Lilian Walther Jallow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objective of this thesis was to develop and improve laboratory methods for detection of HIV-2 in infected humans and detection of HIV-2/SIV in experimentally infected cynomolgus monkeys. Early in the HIV epidemic no assays were commercially available for detection of HIV-2/SIV infections and laboratory testing often relied on cross-reactivity in the assays. LÄS MER

  3. 17. Multiplexed antibody-based protein profiling in the pursuit of CSF biomarkers for neurodegenerative diseases

    Författare :Sofia Bergström; Peter Nilsson; Anna Månberg; Markus Otto; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Protein profiling; suspension bead array; cerebrospinal fluid; biomarker discovery; proteomics; Bioteknologi; Biotechnology;

    Sammanfattning : There is a desire for a transition from generic treatments designed for the average patient, towards more individual-based precision medicine. An increased knowledge about disease pathophysiology on a molecular level would be beneficial for this transition. LÄS MER

  4. 18. Precision mapping of gene expression and proteins in the brain using gene editing and barcoded viral vectors

    Författare :Martino Avallone; Molekylär neuromodulering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene editing; CRISPR Cas9; Barcodes; AAV; PLA; gene therapy; Parkinson’s disease; single nuclei RNAseq; alpha-synuclein;

    Sammanfattning : The human brain is a masterpiece of intricate design and impeccable functionality. It serves as the ultimate command center for our thoughts, sensations, and actions, which define our very existence. LÄS MER

  5. 19. Study the role of patient-specific mutations by genetic disease modeling : From gene to function; A study to understand muscles

    Författare :Martin Dahl-Halvarsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Muscles; Myosin; MYH7; Myosin storage myopathy; Laing early-onset myopathy; Drosophila; TOR1A; DYT1; HCM; heart disease;

    Sammanfattning : Many genetic diseases inherited in a dominant fashion have a complex pathological pattern. TOR1A mediated Dystonia-1 (DYT1) is an example of incomplete penetrance, affecting only a third of the carriers. LÄS MER

  7. 20. Safe labor : reappraisal of labor duration and management for safe maternal and infant outcome

    Författare :Louise Lundborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The partograph, today used worldwide for assessing normal labor progress and identifying prolonged labor is based on Friedman’s research findings from the 1950s, based on 500 deliveries. Friedman established a series of definitions of time parameters, labor curves and phases to detect normal and abnormal labor progress and incorporated it into the Partograph. LÄS MER