Sökning: "synapses"

Visar resultat 1 - 5 av 113 avhandlingar innehållade ordet synapses.

  1. 1. On the Nature of β-Amyloid at Synapses

    Författare :Isak Martinsson; Experimentell demensforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; synapses; APP knockout; beta-Amyloid;

    Sammanfattning : Alzheimer’s disease is an aging related disorder of the mind, accountable for 60-80 percent of all cases of dementia. With its insidious progression and the decline of cognitive abilities, this disease is a major challenge for our society as a whole. LÄS MER

  2. 2. Characterization of Physiological and Pathological Alpha-Synuclein : Implications for Parkinson’s Disease and Related Disorders

    Författare :Leire Almandoz Gil; Joakim Bergström; Martin Ingelsson; Kostas Vekrellis; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Aggregation; Parkinson’s disease; Dementia with Lewy bodies; Oxidative stress; Antibodies; Synapses; SNARE; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. LÄS MER

  3. 3. Flexible Electrical and Photoelectrical Artificial Synapses for Neuromorphic Systems

    Författare :Kunlong Yang; Fernando Seoane; Li-rong Zheng; Juha Plosila; KTH; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Flexible electronics; Neuromorphic network; Memristor; Electron trapping; Electrical artificial synapse; Photoelectrical artificial synapse; Applied Medical Technology; Tillämpad medicinsk teknik;

    Sammanfattning : Over the past decade, the field of personal electronic systems has trended toward mobile and wearable devices. However, the capabilities of existing electronic systems are overwhelmed by the computing demands at the wearable sensing stage. Two main bottlenecks are encountered. LÄS MER

  4. 4. Aspects of memory and representation in cortical computation

    Författare :Martin Rehn; Anders Lansner; Örjan Ekeberg; Peter Földiák; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; cerebral cortex; neural networks; attractor memory; sequence learning; biological vision; generative models; serial order; computational neuroscience; dynamical synapses; Computer science; Datalogi;

    Sammanfattning : Denna avhandling i datalogi föreslår modeller för hur vissa beräkningsmässiga uppgifter kan utföras av hjärnbarken. Utgångspunkten är dels kända fakta om hur en area i hjärnbarken är uppbyggd och fungerar, dels etablerade modellklasser inom beräkningsneurobiologi, såsom attraktorminnen och system för gles kodning. LÄS MER

  5. 5. The interaction between astrocytes and excitatory synapses in health and disease

    Författare :Ipsit Srivastava; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Synaptic transmission forms the basis of neuronal activity and astrocytes play an integral part in this process. Glutamate is the major excitatory neurotransmitter in the brain and an important function of astrocyte during excitatory synaptic activity involves the uptake of glutamate through astrocyte glutamate transporters (EAATs) and hence shaping the excitatory neurotransmission. LÄS MER