Sökning: "retroviral transduction"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden retroviral transduction.

  1. 6. The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer

    Författare :Hayrettin Guven; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Natural killer NK cells; Natural killer-like T NKT cells; Gene transfer; Retrovirus; Good manufacturing practice GMP ; Ex vivo; In vivo; SCID-beige.;

    Sammanfattning : Cell and gene therapy of cancers has received much attention in the past decade. A number of applications of cancer treatment have been developed and used. One of the recent applications is immunotherapy of tumours with human natural killer (NK) cells. LÄS MER

  3. 7. Experimental studies on the effects of hepatocyte-based liver support

    Författare :Helene Lilja; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Liver transplantation is limited by lack of donors and consequently there is a need to develop liver support/replacement therapies, such as hepatocyte transplantation (HcTx) and artificial livers. In the present thesis, the effects of these therapies were investigated. First, we established a technique of isolating fetal hepatocytes (FH). LÄS MER

  4. 8. Immune response during hepatitis B virus infection and reconstitution of HBV-specific immunity using T cells redirected against HBV

    Författare :Sarene Koh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hepatitis B is one of the most prevalent viral diseases worldwide and is a major public health concern, particularly in Asia. Of the 350 million people suffering from chronic hepatitis B virus (HBV) infection worldwide, approximately 75% are found in Asia. LÄS MER

  5. 9. Expression and function of the small immune adaptor protein SAP

    Författare :Noemi Nagy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :XLP; SAP; EBV; BL; lymphocytes; lymphoma; p53; apoptosis; AICD;

    Sammanfattning : The Epstein-Barr virus (EBV) carrier state is widespread in humans. Primary infection can cause infectious mononucleosis (IM) that presents with variable clinical severity, but almost always subsides. For 50% of boys with a rare hereditary immunodeficiency, X-linked lymphoproliferative disease (XLP), primary infection with E13V has a fatal course. LÄS MER

  7. 10. Regulation of the murine immunoglobulin GL gamma-1 and epsilon promoters

    Författare :Lena Ström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system takes advantage of different genetic alterations to amplify its diversity. First at early stages of B cell differentiation when the antigen (ag) receptors are assembled from different gene segments. LÄS MER