Sökning: "Natural killer NK cells"

Visar resultat 1 - 5 av 156 avhandlingar innehållade orden Natural killer NK cells.

1. 1. On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia

   Författare :Brwa Ali Hussein; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Natural killer cells; Acute Myeloid Leukemia; immunotherapy; HDC IL-2; NKG2A; NK education; SNPs; NK activating receptors; HLA class I;

   Sammanfattning : Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. LÄS MER

3. 2. Mechanisms regulating Natural Killer Cell Cytotoxicity

   Författare :Hanna van Ooijen; Björn Önfelt; Karl-Johan Malmberg; Karolin Guldevall; Morgan Huse; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Natural Killer cell; Live-cell microscopy; Single cell; 3D; Microwell;

   Sammanfattning : Over the last 50 years, cancer survival rates have steadily improved thanks to earlier detection and novel treatment regimens. For example, drugs that act on the immune system, so-called immunotherapy, have drastically increased the prospect of survival for patients suffering from some of the most aggressive cancer types including advanced malignant melanoma. LÄS MER

4. 3. The role of natural killer cells and inflammatory mediators in preeclamptic pregnancies

   Författare :Nora Bachmayer; Eva Sverremark-Ekström; Katarina Bremme; Lucia Mincheva-Nilsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; preeclampsia; NK cells; Immunology; Immunologi; immunologi; Immunology;

   Sammanfattning : The maternal immune system must be able to adjust during pregnancy and accept the foetus that expresses paternal antigens. These changes are found both in placenta and circulation, including a mild inflammatory response. NK cells are abundant during the early part of pregnancy in placenta and are thought to be important for placental development. LÄS MER

5. 4. Dendritic cells in cancer immunotherapy

   Författare :Karin Gustafsson; Göteborgs universitet; []
   Nyckelord :vaccines; dendritic cells; αDC1; PGE2DC; natural killer cells; T cells;

   Sammanfattning : Dendritic cells (DCs) play a central role in the initiation and regulation of innate and adaptive immune responses and have increasingly been applied as vaccines for cancer patients. Ex vivo generation and antigen loading of monocyte-derived DCs allows a controlled maturation, with the aim of imprinting different DC functions that are essential for their subsequent induction of a T cell-mediated anti-tumor response. LÄS MER

7. 5. The Role of Plasmacytoid Dendritic Cells and Natural Killer Cells in Systemic Lupus Erythematosus

   Författare :Niklas Hagberg; Lars Rönnblom; Maija-Leena Eloranta; George Tsokos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; plasmacytoid dendritic cells; natural killer cells; type I interferon; immune complex; SLAM receptors; autoantibodies; CD94 NKG2A; CD94 NKG2C; Medicinsk vetenskap; Medical Science; Immunologi; Immunology;

   Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, which can eventually lead to immune complex (IC)-mediated organ damage. Due to the stimulation of plasmacytoid dendritic cells (pDC) by nucleic acid-containing ICs (DNA- or RNA-IC), patients with SLE have an ongoing interferon (IFN)-α production. LÄS MER