Sökning: "reciprocal inhibition"

Visar resultat 11 - 15 av 19 avhandlingar innehållade orden reciprocal inhibition.

  1. 11. Modulation of cellular mechanisms in a spinal locomotor network

    Författare :Jesper Tegnér; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neuronal Network; Calcium Channels; Calcium-DependentPotassium Channels; Neuronal Oscillator; Neuromodulation; GABAg receptors; Lamprey; Locomotion; Spinal Cord; Computer Simulation;

    Sammanfattning : Neuronal networks generate behaviour. Thus, to understand behaviour requires information on how neuronal networks work in terms of their cellular components. The overall aim of this work has been to link processes occurring at an ionic level to the operation of a neural network specialized for undulatory locomotion. LÄS MER

  3. 12. Molecular alterations and clonal evolution in acute myeloid leukemia : prognostic and therapeutic implications

    Författare :Xiaolu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic stem cells characterized by inhibition of differentiation, subsequent accumulation of incomplete matured cells at various stages and reduced production of healthy hematopoietic elements. Despite significant progress, the outcome of AML is variable and often suboptimal. LÄS MER

  4. 13. Protein kinase STK25 is a regulator of hepatic lipid partitioning and whole body metabolism

    Författare :Manoj Amrutkar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NAFLD; NASH; Liver lipid metabolism; Type 2 diabetes; STK25;

    Sammanfattning : In past decade, type 2 diabetes (T2D) and associated metabolic complications have become a major global threat for human health with epidemic increase in incidence. Currently available treatments for T2D have several limitations and side effects making it difficult safely reach adequate metabolic control. LÄS MER

  5. 14. Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 diabetes mellitus

    Författare :Rasmus Sjögren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to targeted genes. LÄS MER

  7. 15. Computational Modelling and Topological Analysis of the striatal microcircuitry in health and Parkinson's disease

    Författare :Ilaria Carannante; Jeanette Hellgren Kotaleski; Alexander Kozlov; Sean Hill; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Datalogi; Computer Science;

    Sammanfattning : The basal ganglia are evolutionary conserved nuclei located at the base of the forebrain. They are a central hub in the control of motion and their dysfunctions lead to a variety of movement related disorders, including Parkinson's disease (PD).The largest nucleus and main input stage of the basal ganglia is the striatum. LÄS MER