Sökning: "reactive drug administration"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden reactive drug administration.

  1. 1. Evaluating and optimizing surveillance and response strategies for malaria elimination in the Asia Pacific region

    Författare :Chris Cotter; Andreas Mårtensson; Arantxa Roca-Feltrer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; malaria elimination; surveillance and response; reactive case detection; sociobehavorial; reactive drug administration; molecular diagnostics; microsatellite genotyping; Plasmodium vivax; low transmission;

    Sammanfattning : Malaria case investigation and reactive case detection (RACD) activities are widely implemented in low transmission settings to identify additional malaria infections and gather surveillance information, but with varying degrees of success. Challenges in conducting RACD include poor diagnostic sensitivity (particularly for low density and asymptomatic infections), knowledge gaps among those conducting RACD, financial and resource constraints, and operational and logistical difficulties. LÄS MER

  3. 2. A Fully Integrated Microneedle-based Transdermal Drug Delivery System

    Författare :Niclas Roxhed; Göran Stemme; Mark G. Allen; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microneedle; Transdermal; Intradermal; Drug delivery; DRIE; MEMS; Microsystem; Medical technology; Medicinsk teknik;

    Sammanfattning : Patch-based transdermal drug delivery offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections relating to issues such as patient acceptability and injection safety. However, conventional transdermal drug delivery is limited to therapeutics where the drug can diffuse across the skin barrier. LÄS MER

  4. 3. Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis

    Författare :Malin Graffner Nordberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; soft drug; dihydrofolate reductase; synthesis; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Sammanfattning : The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treatment of many diseases, including cancer, bacterial and protozoal infections, and also opportunistic infections associated with AIDS (Pneumocystis carinii pneumonia, PCP). LÄS MER

  5. 4. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage

    Författare :Faranak Azarbayjani; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Atiepileptik drugs; embryonic heart; arrhythmia; cleft palate; ROS; antioxidants; Ikr; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. LÄS MER

  7. 5. Bioactive nanocellulose materials for the treatment of chronic wounds

    Författare :Anna Blasi Romero; Natalia Ferraz; Daniel Aili; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; cellulose nanofibrils; covalent immobilization; wound healing; antioxidant properties; antibacterial properties; anti-inflammatory properties; stimuli responsive hydrogels; reactive oxygen species; host defense peptides; Teknisk fysik med inriktning mot nanoteknologi och funktionella material; Engineering Science with specialization in Nanotechnology and Functional Materials;

    Sammanfattning : Chronic wounds represent a burden for the healthcare system and significantly affect the quality of life of the patients. There is currently a lack of efficient treatments but new, improved therapeutic approaches are under development. LÄS MER