Sökning: "radioimmunotargeting"

Hittade 5 avhandlingar innehållade ordet radioimmunotargeting.

  1. 1. Strategies to improve cancer radioimmunotargeting

    Författare :Anders Ullén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : cancer; monoclonal antibody; antiidiotypic antibody; radioimmunotargeting; placental alkaline phosphatase; cytokeratin; BIAcore.;

    Sammanfattning : Radioimmunotherapy (RIT) and radioimmunolocalisation (RIL) are developing and promising technologies to diagnose and treat tumours by use of radiolabelled antibodies targeting tumour specific antigens. The major reason why RIL and RIT not are efficient enough, is the comparatively low accumulation of radiolabelled antibodies in the tumours. LÄS MER

  3. 2. Improving radioimmunotargeting of tumors : the impact of extracorporeal immunoadsorption and preload in rats

    Författare :Michael Garkavij; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; preload.; immunoadsorption; MAb; rat; Tumor; radioimmunotargeting; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : In radioimmunotherapy of tumors, uptake of the monoclonal antibody (MAb) used is often too low in relation to its uptake in normal tissues. The purpose of these studies was to improve experimental tumor radioimmunotargeting with (a) extracorporeal immunoadsorption (ECIA), where excess of radiolabeled MAbs circulating in blood is removed, (b) or by preload with unlabeled MAb prior to injection of radiolabeled MAb, (c) or by a combination of these. LÄS MER

  4. 3. Radioimmunotargeting of cancer cells : studies on prostatic adenocarcinoma spheroids and characterization of a novel monoclonal anti-prostate antibody

    Författare :Magnus Essand; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  5. 4. Radioimmunodiagnosis of Head and Neck Squamous Cell Carcinomas : Preclinical Studies

    Författare :Karl Sandström; Matti Anniko; Marika Nestor; Hans Lundqvist; Göran Laurell; Uppsala universitet; []
    Nyckelord :Head and neck squamos cell carcinoma; radioimmunotargeting; radioimmunodiagnosis; MEDICINE; MEDICIN;

    Sammanfattning : Despite improvements in treatment, the prognosis for patients with advanced head and neck squamous cell carcinomas (HNSCC) has only improved to a minor degree. To raise the success rate and minimize morbidity further developments in diagnostics are highly desired. Radioimmunodiagnosis could offer a more specific and sensitive diagnostic method. LÄS MER

  7. 5. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer

    Författare :Marika Nestor; Matti Anniko; Jörgen Carlsson; Hans Lundqvist; Vladimir Tolmachev; Matthew Robinson; Uppsala universitet; []
    Nyckelord :Otorhinolaryngology; antibodies; radionuclide targeting; tumour targeting; therapy; diagnostics; immuno-PET; head and neck squamous cell carcinoma; Otorhinolaryngologi;

    Sammanfattning : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. LÄS MER