Sökning: "MAb"
Visar resultat 1 - 5 av 105 avhandlingar innehållade ordet MAb.
1. Improving radioimmunotargeting of tumors : the impact of extracorporeal immunoadsorption and preload in rats
Sammanfattning : In radioimmunotherapy of tumors, uptake of the monoclonal antibody (MAb) used is often too low in relation to its uptake in normal tissues. The purpose of these studies was to improve experimental tumor radioimmunotargeting with (a) extracorporeal immunoadsorption (ECIA), where excess of radiolabeled MAbs circulating in blood is removed, (b) or by preload with unlabeled MAb prior to injection of radiolabeled MAb, (c) or by a combination of these. LÄS MER
2. Tumor-targeted superantigens for experimental immunotherapy of human leukemia/lymphoma
Sammanfattning : Bacterial superantigens (SAgs) have the property of stimulating high proportions of T cells expressing certain TCR Vβ sequences. The SAg first binds with high affinity to HLA class II molecules on the target cell and then stimulates the T cell to produce cytokines and to become cytotoxic. LÄS MER
3. Computational prediction of novel MAB phases
Sammanfattning : The synthesis procedure of any materials system is often considered a challenging task if performed without any prior knowledge. Theoretical models may thus be used as an external input and guide experimental efforts toward novel exotic materials which are most likely to be synthesizable. LÄS MER
4. Radioimmunotherapy in an Immunocompetent Tumor Model utilizing a 177Lu-mAb
Sammanfattning : Radioimmunotherapy (RIT) is a therapeutic strategy in which radionuclides are conjugated to monoclonal antibodies that bind to tumor-associated antigens in the tumor, so that the decay of the radionuclide takes place inside the tumor. The aim of the research presented in this thesis was to investigate the effects of RIT (utilizing the radioconjugated antibody 177Lu-BR96) on an inoculated tumor and the development of metastases. LÄS MER
5. Immunotherapy in cancer and HIV
Sammanfattning : Two major threats to human health are cancer and human immunodeficiency virus (HIV) infection. In both cases, a feature of progress of the disease is a defective immune function. Immunological mechanisms have evolved whereby transformed cells and HIV-1 infected cells avoid recognition and elimination by the immune system. LÄS MER
